Association between genetic variants in the XPG gene and gastric cancer risk in a Southern Chinese population
| Autor: | Wen Qiong Xue, Guo Ping Shen, Dan Hua Jiang, Jing He, Zhenjian Zhuo, Xi Zhao Li, Shao Dan Zhang, Rui-Xi Hua, Wei Hua Jia, Jinhong Zhu, Jiang Bo Zhang, Pei Fen Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Oncology Male Aging medicine.medical_specialty China Xeroderma pigmentosum XPG Genotype DNA repair Population Biology Bioinformatics Polymorphism Single Nucleotide polymorphism 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Stomach Neoplasms Internal medicine medicine Genetic predisposition Humans education education.field_of_study gastric cancer Cancer Nuclear Proteins Cell Biology Odds ratio Middle Aged medicine.disease Endonucleases DNA-Binding Proteins 030104 developmental biology 030220 oncology & carcinogenesis Female Research Paper genetic susceptibility Transcription Factors |
| Zdroj: | Aging (Albany NY) |
| ISSN: | 1945-4589 |
| Popis: | Xeroderma pigmentosum group G (XPG) recognizes and excises DNA damage on the 3' side during the DNA repair process. Previous studies indicated that XPG gene polymorphisms may associate with gastric cancer susceptibility, but results were inconsistent. We evaluated the association of five potentially functional XPG polymorphisms (rs2094258 C>T, rs751402 C>T, rs2296147 T>C, rs1047768 T>C, and rs873601 G>A) with gastric cancer susceptibility in 1142 gastric cancer cases and 1173 controls. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using logistic regression models. Overall, no significant association was detected between any of selected polymorphism and gastric cancer risk. However, we found that individuals carrying 3-4 risk genotypes were at significantly higher risk of gastric cancer than those with 0-2 risk genotypes (OR=1.32, 95% CI=1.04-1.68, P=0.021). The stratification analysis revealed that the cumulative effect of risk genotypes (3-4 vs. 0-2) on gastric cancer were more prominent among subgroups older than 58 years and men. In conclusion, our results indicated that none of the selected XPG polymorphism could significantly alter gastric cancer susceptibility alone. These polymorphisms might collectively confer increased gastric cancer susceptibility. These findings would be strengthened by larger prospective multicenter studies involving different ethnic populations. |
| Databáze: | OpenAIRE |
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