Haemodynamic Influences of Bisoprolol in Hypertensive Middle-Aged Men: A Double-Blind, Randomized, Placebo-Controlled Cross-Over Study
| Autor: | Jenni Koskela, Lauri Suojanen, Mika Kähönen, Arttu Eräranta, Anna Tahvanainen, Kari T. Kivistö, Jukka Mustonen, Antti Haring, Antti Tikkakoski, Kalle Sipilä, Ilkka Pörsti, Heini Huhtala |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male Cardiac output Hemodynamics Blood Pressure 030204 cardiovascular system & hematology Pulse Wave Analysis Toxicology Cardiography Impedance Severity of Illness Index 03 medical and health sciences 0302 clinical medicine Vascular Stiffness Double-Blind Method Heart rate medicine Bisoprolol Humans 030212 general & internal medicine Cardiac Output Pulse wave velocity Antihypertensive Agents Pharmacology Cross-Over Studies business.industry Heart Stroke Volume General Medicine Stroke volume Middle Aged Adrenergic beta-1 Receptor Antagonists Blood pressure medicine.anatomical_structure Anesthesia Vascular resistance Vascular Resistance Essential Hypertension business medicine.drug |
| Zdroj: | Basicclinical pharmacologytoxicology. 121(2) |
| ISSN: | 1742-7843 |
| Popis: | Treatment with beta-blockers appears to show inferior reduction in central versus peripheral blood pressure. We aimed to examine simultaneous changes in central and peripheral blood pressure, vascular resistance, cardiac function and arterial stiffness during beta-blockade. Haemodynamics were investigated after 3 weeks of bisoprolol treatment (5 mg/day) in a double-blind, randomized, placebo-controlled cross-over trial in never-treated 16 Caucasian males with grade I-II primary hypertension using continuous tonometric pulse wave analysis and whole-body impedance cardiography. Bisoprolol decreased radial (134/80 versus 144/89 mmHg) and aortic blood pressure (122/80 versus 130/90 mmHg) and heart rate (57 versus 68 beats/min) when compared with placebo (p < 0.05 for all). Ejection duration (336 versus 316 ms) and stroke volume (109 versus 98 ml) were increased (p < 0.01 for all), while cardiac output was not significantly changed (6.2 versus 6.6 l/min). Bisoprolol decreased pulse wave velocity (7.8 versus 8.9 m/s, p < 0.001), but after adjustment for blood pressure, the decrease was not significant (8.16 versus 8.52 m/s, p = 0.464). The treatment reduced pulse pressure amplification from central to peripheral circulation (30 versus 38%, p = 0.002). No differences were observed in systemic vascular resistance, augmentation index, aortic characteristic impedance or total arterial stiffness after bisoprolol versus placebo. Bisoprolol decreased central and peripheral blood pressure and pulse wave velocity in male individuals with grade I to grade II hypertension. The decrease in pulse wave velocity was related to the antihypertensive effect. Reduced pulse pressure amplification indicates that peripheral blood pressure was reduced more efficiently than central blood pressure. |
| Databáze: | OpenAIRE |
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