Iron Heterogeneity in Early Active Multiple Sclerosis Lesions

Autor: Christopher A. Robinson, Claudia F. Lucchinetti, Yong Guo, Reginald C. Adiele, Samuel M. Webb, Wolfgang Brück, Kendra L Furber, M. Jake Pushie, Hans Lassmann, Joseph E. Parisi, Stephen D. Weigand, Josa M. Frischer, Mylyne Tham, Patrick D. Fitz-Gibbon, Bogdan F. Gh. Popescu
Rok vydání: 2020
Předmět:
Male
0301 basic medicine
Pathology
Apoptosis
Autopsy
Ferric Compounds
0302 clinical medicine
Child
Research Articles
medicine.diagnostic_test
Optical Imaging
Brain
Middle Aged
Immunohistochemistry
3. Good health
Myelin-Associated Glycoprotein
Oligodendroglia
medicine.anatomical_structure
Neurology
Female
Myelin Proteins
Research Article
Adult
medicine.medical_specialty
Multiple Sclerosis
Adolescent
Iron
Macrophage polarization
Immunoglobulins
White matter
Young Adult
03 medical and health sciences
Biopsy
medicine
Humans
Ferrous Compounds
Aged
business.industry
Macrophages
Multiple sclerosis
Spectrometry
X-Ray Emission
Magnetic resonance imaging
Histology
Complement System Proteins
medicine.disease
030104 developmental biology
Apoferritins
Neurology (clinical)
business
Synchrotrons
030217 neurology & neurosurgery
Zdroj: Annals of Neurology
ISSN: 1531-8249
0364-5134
DOI: 10.1002/ana.25974
Popis: OBJECTIVE Multiple sclerosis (MS) is a heterogeneous inflammatory demyelinating disease. Iron distribution is altered in MS patients' brains, suggesting iron liberation within active lesions amplifies demyelination and neurodegeneration. Whether the amount and distribution of iron are similar or different among different MS immunopatterns is currently unknown. METHODS We used synchrotron X-ray fluorescence imaging, histology, and immunohistochemistry to compare the iron quantity and distribution between immunopattern II and III early active MS lesions. We analyzed archival autopsy and biopsy tissue from 21 MS patients. RESULTS Immunopattern II early active lesions contain 64% more iron (95% confidence interval [CI] = 17-127%, p = 0.004) than immunopattern III lesions, and 30% more iron than the surrounding periplaque white matter (95% CI = 3-64%, p = 0.03). Iron in immunopattern III lesions is 28% lower than in the periplaque white matter (95% CI = -40 to -14%, p
Databáze: OpenAIRE
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