Levamisole and its influence on the immune response of lambs
| Autor: | W. Cabaj, M. Stankiewicz, W.E. Jonas, L G Moore |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cellular immunity
medicine.medical_specialty Erythrocytes T-Lymphocytes Biology Lymphocyte Activation Animal science Antigen Internal medicine medicine Animals Anthelmintic Insulin-Like Growth Factor I Cells Cultured Phytohaemagglutinin B-Lymphocytes Immunity Cellular Sheep General Veterinary General Medicine Levamisole Ovalbumin Endocrinology Concanavalin A Growth Hormone Antibody Formation biology.protein Antibody medicine.drug |
| Zdroj: | Veterinary Research Communications. 19:17-26 |
| ISSN: | 1573-7446 0165-7380 |
| DOI: | 10.1007/bf01839248 |
| Popis: | Ten parasite-free lambs were drenched with 8 mg/kg of levamisole on days 0 and 28 and were injected with human erythrocytes and ovalbumin one day after each drench. Ten other antigen-injected lambs were not drenched with anthelmintic as controls. Lymphocytes from the control and drenched lambs were cultured in vitro with RPMI 1640 plus 5% fetal calf serum (FCS), with 50% autologous serum only, with concanavalin A (Con A) or with phytohaemagglutinin (PHA). Decreased blastogenesis was observed in cells from the drenched lambs cultured in the presence or absence of mitogen and was most obvious when 50% autologous serum was used, particularly with PHA, and when lymphocytes were collected 3 and 7 days after the first and 3 days after the second antigen injection. There were no significant changes in antibody titres between the groups. Decreased serum complement activity was seen 3 days after the second antigen injection in the drenched lambs. Although there was a significant reduction in the serum insulin-like growth factor I levels 4 days after each levamisole drench, the drenched lambs gained significantly more weight than the non-drenched control lambs. |
| Databáze: | OpenAIRE |
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