Cardiac Troponins and Renal Function in Nondialysis Patients with Chronic Kidney Disease
| Autor: | Nasir A. Abbas, Aisling N. Potter, Michelle C. Webb, Michelle E. Kempson, Susan Vickery, R. Ian John, Christopher P. Price, Edmund J. Lamb |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Clinical Biochemistry Renal function macromolecular substances Kidney Function Tests Left ventricular hypertrophy Troponin T Troponin complex Internal medicine Troponin I medicine Humans Prospective Studies Survival rate Dialysis Aged Uremia biology business.industry Biochemistry (medical) Middle Aged medicine.disease Troponin Survival Rate cardiovascular system Cardiology biology.protein Kidney Failure Chronic Female Hypertrophy Left Ventricular business Kidney disease |
| Zdroj: | Clinical Chemistry. 51:2059-2066 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1373/clinchem.2005.055665 |
| Popis: | Background: Serum cardiac troponin concentrations are commonly increased in end-stage renal disease (ESRD) in the absence of an acute coronary syndrome (ACS). The data on cardiac troponin I (cTnI) are more variable than those for cardiac troponin T (cTnT). There is little information on cardiac troponin concentrations in patients with chronic kidney disease (CKD) who have not commenced dialysis.Methods: We studied 222 patients: 56 had stage 3 (moderate CKD); 70 stage 4 (severe CKD); and 96 stage 5 (kidney failure). Patients underwent echocardiography and were followed prospectively for a median of 19 months; all-cause mortality was recorded.Results: Overall, serum cTnT was increased above the 99th percentile reference limit in 43% of all CKD patients studied, compared with 18% for cTnI. Serum cTnT and cTnI concentrations were more commonly increased in the presence of more severe CKD (11 and 6 patients in stage 3, 27 and 8 in stage 4, and 57 and 24 in stage 5 (P Conclusions: Increased cTnT and cTnI concentrations are relatively common in predialysis CKD patients, in the absence of an ACS, including among those with stage 3 disease. The presence of left ventricular hypertrophy alone does not explain these data. Detectable cTnT was a marker of decreased survival. |
| Databáze: | OpenAIRE |
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