Predictors of subclinical atherosclerosis evaluated by carotid intima-media thickness in asymptomatic young women with type 1 diabetes mellitus
| Autor: | Joana Rodrigues Dantas Pereira, Isabela Bussade, Marcio Antonio Epifanio, Claudio Domenico Sahione Schettino, Manuella Rangel Larrúbia, Rosane Kupfer, Denise Prado Momesso, Giovanna A. Balarini Lima |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Endocrinology
Diabetes and Metabolism lcsh:Medicine 030204 cardiovascular system & hematology lcsh:Diseases of the endocrine glands. Clinical endocrinology Body Mass Index chemistry.chemical_compound 0302 clinical medicine Risk Factors insulin resistance Middle Aged C-Reactive Protein Cholesterol Type 1 diabetes Obesity Abdominal Cardiology cardiovascular system Female medicine.symptom Adult medicine.medical_specialty subclinical atherosclerosis carotid intima-media thickness 030209 endocrinology & metabolism Risk Assessment Asymptomatic Statistics Nonparametric 03 medical and health sciences Insulin resistance Internal medicine medicine Humans cardiovascular diseases Triglycerides Enzyme Assays lcsh:RC648-665 central obesity business.industry lcsh:R Ultrasonography Doppler Atherosclerosis medicine.disease Cross-Sectional Studies Diabetes Mellitus Type 1 Endocrinology chemistry Intima-media thickness Asymptomatic Diseases Albuminuria Glycated hemoglobin Metabolic syndrome business Body mass index |
| Zdroj: | Archives of Endocrinology and Metabolism, Vol 61, Iss 2, Pp 115-121 (2017) Archives of Endocrinology and Metabolism, Volume: 61, Issue: 2, Pages: 115-121, Published: 16 FEB 2017 Archives of Endocrinology and Metabolism v.61 n.2 2017 Arquivos de Endocrinologia e Metabolismo Sociedade Brasileira de Endocrinologia e Metabologia (SBEM) instacron:SBEM |
| ISSN: | 2359-4292 |
| Popis: | Objective This study aimed to evaluate the occurrence and clinical predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. Subjects and methods The study included 45 women with type 1 diabetes mellitus (DM) (aged 36 ± 9 years) who underwent carotid Doppler ultrasound evaluation to determine the carotid artery intima-media thickness (CIMT) and to assess the occurrence of carotid artery plaques. Insulin sensitivity was assessed by estimated glucose disposal rate (eGDR), and metabolic syndrome (MS) was defined by the World Health Organization criteria. Results The cohort had a mean age of 36 ± 9 years, diabetes duration of 18.1 ± 9.5 years, and body mass index (BMI) of 24.6 ± 2.4 kg/m2. MS was present in 44.4% of the participants. The CIMT was 0.25 ± 0.28 mm, and the prevalence of carotid artery plaques was 13%. CIMT correlated positively with hypertension (p = 0.04) and waist-to-hip ratio (r = 0.37, p = 0.012). The presence of carotid artery plaques correlated positively with age (p = 0.018) and hypertension (p = 0.017). eGDR correlated negatively with CIMT (r = -0.39, p = 0.009) and carotid plaques (p = 0.04). Albuminuria showed a correlation trend with CIMT (p = 0.06). Patients with carotid artery plaques were older, had a higher prevalence of hypertension, and lower eGDR. No correlation was found between CIMT and carotid plaques with diabetes duration, MS, BMI, cholesterol profile, glycated hemoglobin, high-sensitivity C-reactive protein, or fibrinogen. Conclusion Insulin resistance, central obesity, hypertension, and older age were predictors of subclinical atherosclerosis in asymptomatic, young adult women with type 1 DM. |
| Databáze: | OpenAIRE |
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