Inhibition of in vitro RNA synthesis by hycanthone, oxamniquine and praziquantel
| Autor: | G. C. Tsao, L. J. C. Wong, S. S. Wong, John I. Bruce |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Schistosomicides
Hamster Hycanthone Biology Pharmacology Praziquantel Cellular and Molecular Neuroscience Cricetinae parasitic diseases medicine Animals Mode of action Molecular Biology Cell Nucleus Nitroquinolines Cell Biology DNA Oxamniquine In vitro Mechanism of action Liver Depression Chemical Thioxanthenes Molecular Medicine RNA medicine.symptom medicine.drug |
| Zdroj: | Experientia. 46(5) |
| ISSN: | 0014-4754 |
| Popis: | The schistosomicides, hycanthone, oxamniquine and praziquantel, were found to inhibit the in vitro RNA synthesis using isolated hamster liver nuclei. Preincubation of the nuclei with these drugs revealed that the inhibitory effect of oxamniquine was irreversible and progressed with time, whereas that of hycanthone and parziquantel was reversible. On the other hand, hycanthone and praziquantel have a high affinity for DNA but oxamniquine does not. The data indicate that the mechanism of inhibition by oxamniquine is different from that of hycanthone and praziquantel. |
| Databáze: | OpenAIRE |
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