Effects of Angiotensin Converting Enzyme Inhibitor and Angiotensin II Type 1 Receptor Blocker on Cardiac Dysfunction Induced by Isoproterenol in Dogs
| Autor: | Yin-Tie Jin, Shinsuke Kido, Kenjiro Kikuchi, Takafumi Ohta, Naoyuki Hasebe, Motohiko Sato, Shiro Tsuji, Shunsuke Natori |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Lipid Peroxides medicine.medical_specialty Heart Diseases Angiotensin-Converting Enzyme Inhibitors urologic and male genital diseases Receptor Angiotensin Type 1 Quinaprilat Angiotensin Receptor Antagonists Ventricular Dysfunction Left Dogs Isoprenaline Internal medicine medicine Animals Creatine Kinase MB Form cardiovascular diseases Creatine Kinase Pharmacology L-Lactate Dehydrogenase biology Lipid peroxide Chemistry Angiotensin II Hemodynamics Isoproterenol Angiotensin-converting enzyme Adrenergic beta-Agonists medicine.disease female genital diseases and pregnancy complications Isoenzymes Candesartan Endocrinology Heart failure ACE inhibitor biology.protein Female Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 38:S63-S67 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-200110001-00014 |
| Popis: | We examined whether angiotensin converting enzyme (ACE) inhibitors and angiotensin II type 1 receptor blockers (ARB) prevent isoproterenol (ISO)-induced left ventricular (LV) dysfunction in dogs. The effects of a large dose of ISO, 1 microg/kg/min, 3 h infusion, were investigated in three groups with simultaneous infusion of an ACE inhibitor (quinaprilat), ARB (candesartan) or saline. ISO infusion significantly decreased LV dP/dt, LV ejection fraction and LV fractional shortening, and significantly increased tau, the time constant of isovolume relaxation of LV, and LV end diastolic pressure. All of these changes were significantly attenuated in both the ACE inhibitor and ARB groups, especially in the ARB group. Serum levels of creatinin kinase isoform MB, lactate dehydrogenase and lipid peroxide were significantly increased by ISO. However, the increases in these markers of myocardial damage were significantly diminished by simultaneous infusion of an ACE inhibitor or ARB, especially by ARB. In conclusion, an ACE inhibitor and ARB prevent LV systolic and diastolic dysfunction as well as myocardial damage induced by excess beta-adrenergic stimulation. |
| Databáze: | OpenAIRE |
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