Association between cadmium exposure and diabetes mellitus risk: a prisma-compliant systematic review and meta-analysis
| Autor: | Guanglei Huang, Chen Zhu, Ke Zhao, Jukun Song, Lingkai Su, Jianguo Zhu, Xinhai Yin, Zhuhui Duan, Wang Yadong, Ming Wu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
cadmium Population 010501 environmental sciences 01 natural sciences 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine 030212 general & internal medicine Risk factor education Prospective cohort study 0105 earth and related environmental sciences education.field_of_study business.industry Odds ratio Publication bias medicine.disease Confidence interval Oncology Meta-analysis diabetes mellitus business Meta-Analysis |
| Zdroj: | Oncotarget |
| ISSN: | 1949-2553 |
| Popis: | Cadmium (Cd) is a pollutant with multiple adverse health effects: cancer, renal dysfunction, osteoporosis and fracture, and cardiovascular disease. Several population-based studies found an association between Cd and diabetes mellitus (DM), but this association is inconsistent with other research. We conducted meta-analysis to examine relationship between urinary/blood Cd exposure and DM risk. Pertinent studies were identified by searching PubMed and Embase databases, and combined odds ratio (OR) and corresponding 95% confidence interval (CI) were applied to evaluate said association. Meta-analysis showed that high U-Cd exposure is not correlated with DM risk (OR = 1.19; 95% CI = 0.83-1.71), and high B-Cd exposure is also not associated with increased risk of DM (OR = 1.16; 95% CI = 0.84-1.62) in the general population. Subgroup and sensitivity analysis proved similar results, with little evidence of publication bias. This meta-analysis suggests that high U-Cd/B-Cd exposure may not be risk factor for DM in general populations. However, large prospective studies are needed to confirm this finding. |
| Databáze: | OpenAIRE |
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