An Efficacious Protocol for 4-Substituted 3,4-Dihydropyrimidinones: Synthesis and Calcium Channel Binding Studies
| Autor: | Divya Arora, Danielle Falkowski, Qingxin Liu, Robert S. Moreland, Kamaljit Singh |
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| Rok vydání: | 2009 |
| Předmět: |
Chiral auxiliary
Chemistry Calcium channel Organic Chemistry Biginelli reaction chemistry.chemical_element Regioselectivity Calcium Combinatorial chemistry Chemical synthesis Article chemistry.chemical_compound Enantiopure drug Organic chemistry Calcium Channel Binding Physical and Theoretical Chemistry |
| Zdroj: | European Journal of Organic Chemistry. 2009:3258-3264 |
| ISSN: | 1099-0690 1434-193X |
| DOI: | 10.1002/ejoc.200900208 |
| Popis: | Ethyl 1,2-dihydro-1,6-dimethyl/6-methyl-2-oxopyrimidine-5-carboxylates react with C-nucleophiles as well as the anion of the enantiopure chiral auxiliary (1R,2S,5R)-(–)-methyl (S)-p-toluenesulfinate to afford 4-substituted and enantiopure congeners of medicinally potent Biginelli dihydropyrimidinones. The calcium channel blocking activity of some of the compounds was evaluated and compared with nifedipine for their ability to relax a membrane depolarization-induced contraction.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009) |
| Databáze: | OpenAIRE |
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