Plasma total homocysteine in healthy subjects: sex-specific relation with biological traits
| Autor: | Suzanne Lussier-Cacan, Marianne Xhignesse, Alain Piolot, Jacques Genest, Jean Davignon, Jacob Selhub |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Vitamin medicine.medical_specialty Homocysteine Health Status Medicine (miscellaneous) chemistry.chemical_compound Folic Acid Reference Values Internal medicine Blood plasma medicine Humans Vitamin B12 Cyanocobalamin Sex Characteristics Creatinine Nutrition and Dietetics Middle Aged Pyridoxine Vitamin B 12 Endocrinology chemistry Pyridoxal Phosphate Regression Analysis Uric acid Female medicine.drug |
| Zdroj: | The American Journal of Clinical Nutrition. 64:587-593 |
| ISSN: | 0002-9165 |
| Popis: | Fasting plasma total homocysteine (tHcy) concentration was measured in 380 men and 204 women selected for health on the basis of clinical history, physical examination, and normal results of a biochemical profile. We sought to define tHcy reference values in healthy individuals and to determine relations between tHcy and plasma folic acid, vitamin B-12, and pyridoxal phosphate (vitamin B-6) concentrations. Men had significantly higher plasma tHcy than women (9.7 +/- 4.9 compared with 7.6 +/- 4.1 mumol/L, x +/- SD) and lower folate concentrations (8.6 +/- 5.2 compared with 9.8 +/- 6.6 nmol/L, P < 0.05). Significant correlations were found between tHcy and uric acid, creatinine, albumin, folate, and vitamin B-12 concentrations. There was no correlation with age, body mass index, blood pressure, glucose, and total and lipoprotein lipids. When divided in quartiles of vitamin concentrations, subjects with the lowest vitamin B-12 and folate values had significantly higher tHcy concentrations than those in the other three quartiles. Interestingly, after exclusion of subjects in the lowest quartiles of folate and vitamin B-12 concentration, correlations between tHcy and vitamin concentrations were no longer observed, except for vitamin B-12 in men. Stepwise-multiple-regression analyses showed that the sex-specific influence of biological variables on tHcy concentrations was twice as important in healthy women than in healthy men. This study emphasizes the significance of sex-associated differences in the biology of homocysteine and underlines the importance of considering these in the determination of threshold values. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|