Digital computer simulation study of the radio-Hippuran renogram
| Autor: | J.D. Horgan, J.A. Madden, T.A. Torzala, R.C. Meade |
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| Rok vydání: | 1967 |
| Předmět: |
Digital computer
Cardiac output Radiation Computers business.industry Transit time Effective renal plasma flow Plasma volume Renal artery stenosis medicine.disease Models Biological Nuclear Energy and Engineering Renal blood flow Medicine Iodohippuric Acid Radiology Nuclear Medicine and imaging business Nuclear medicine Radioisotope Renography |
| Zdroj: | The International Journal of Applied Radiation and Isotopes. 18:797-808 |
| ISSN: | 0020-708X |
| DOI: | 10.1016/0020-708x(67)90001-4 |
| Popis: | A digital computer model of the radio-Hippuran renogram has been developed to simulate the normal renogram previously described for this laboratory. The parameters used correspond to previously established physiologic values whenever such data were available, e.g. plasma volume, effective renal plasma flow, renal transit time and cardiac output. The apparent Hippuran space and body background were determined from patient studies. Intercompartmental transfer and intra-renal mixing rates were of necessity computer derived from the best fit. The model gives an estimate within ±5 per cent of the mean normal renogram and the 30-min excretion. Model results do not correspond as closely to the apparent Hippuran space. A simultaneous good fit of all three results does not appear possible with any combination of parameters which differ greatly from the values used. The model successfully simulates disease states, such as reduction in renal blood flow, mechanical obstruction and renal artery stenosis. |
| Databáze: | OpenAIRE |
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