Effect of Highly Active Antiretroviral Therapy on Incidence of Early Syphilis in HIV-Infected Patients
| Autor: | Sung-Han Kim, Myoung Don Oh, Wan Beom Park, Kang Won Choe, Nam Joong Kim, Hong Bin Kim, Hee-Chang Jang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Microbiology (medical) Sexually transmitted disease Pediatrics medicine.medical_specialty Primary Syphilis HIV Infections Dermatology Acquired immunodeficiency syndrome (AIDS) Antiretroviral Therapy Highly Active medicine Humans Syphilis Sida Korea biology business.industry Incidence Incidence (epidemiology) Public Health Environmental and Occupational Health virus diseases Middle Aged medicine.disease biology.organism_classification Surgery Infectious Diseases Regression Analysis Female Viral disease business Treponematosis |
| Zdroj: | Sexually Transmitted Diseases. 35:304-306 |
| ISSN: | 0148-5717 |
| Popis: | The objectives were to evaluate the incidence of early syphilis based on time from initiation of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)-infected patients. Five hundred thirty-nine HIV-positive patients undergoing HAART were followed up to 4 years to identify early (primary or secondary) syphilis. Incidence rate trends according to time from HAART initiation were evaluated by Poisson regression after adjustment for calendar year. With median follow-up of 2.9 years 56 (10.4%) patients experienced early syphilis 17 (3.2%) with primary syphilis and 39 (7.2%) with secondary syphilis. The overall incidence rate of early syphilis for 4 years after the start of HAART was 4.57 per 100 person-years (95% confidence interval 3.45-5.93). The incidence rate of early syphilis significantly increased in proportion to the years after the start of HAART (3.4-6.1 per 100 person-year P for trend less than 0.001). Early syphilis incidence in HIV-infected patients increased in proportion to HAART duration. The finding suggests that screening for syphilis in HIV-infected patients who initiate HAART should be encouraged with attention to the time passed since HAART initiation. (authors) |
| Databáze: | OpenAIRE |
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