A national Swedish case-control study investigating incidence and factors associated with idiopathic intracranial hypertension
| Autor: | Sarah Burkill, A Ingela M Nilsson Remahl, Shahram Bahmanyar, Elisabet Waldenlind, Anna Sundholm |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Sweden
Pediatrics medicine.medical_specialty Pseudotumor Cerebri business.industry Incidence (epidemiology) case-control study Incidence Case-control study General Medicine Pseudotumor cerebri syndrome Original Articles Idiopathic intracranial hypertension Pregnancy pseudotumor cerebri syndrome Case-Control Studies medicine risk factors Humans Female Neurology (clinical) Obesity Intracranial Hypertension business |
| Zdroj: | Cephalalgia |
| ISSN: | 1468-2982 0333-1024 |
| Popis: | Objective To study the incidence of idiopathic intracranial hypertension in Sweden and to explore whether previously proposed risk factors are associated with idiopathic intracranial hypertension by investigating the odds of exposure one year prior to diagnosis in patients compared to controls. Methods Using Swedish health care registers and validated diagnostic algorithms, idiopathic intracranial hypertension patients diagnosed between 2000–2016 were compared with randomly selected matched controls, five from the general population and five with obesity. Results We identified 902 idiopathic intracranial hypertension patients and 4510 matched individuals in each control group. Mean incidence among inhabitants ≥18 years of age was 0.71 per 100,000; rising from 0.53 in 2000–2005 to 0.95 in 2012–2016. There were increased odds for idiopathic intracranial hypertension patients compared to general population for exposure to: kidney failure (odds ratio =13.2 (4.1–42.0)), arterial hypertension (odds ratio =17.5 (10.5–29.3)), systemic lupus erythematosus (odds ratio =13.8 (4.3–44.7)), tetracyclines, sulphonamides, lithium, and corticosteroids. In obese controls, odds ratios were also significantly increased for these exposures. Hormonal contraceptive use and exposure to pregnancy did not appear to be associated factors for idiopathic intracranial hypertension development. Conclusions The incidence of idiopathic intracranial hypertension in Sweden is lower relative to reports from other countries but is on the rise. This case-control study confirms several previously reported risk factors associated with idiopathic intracranial hypertension. |
| Databáze: | OpenAIRE |
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