Trimodality therapy for superior sulcus tumours: Evolution and evaluation of a treatment protocol
| Autor: | J.L.G. Blaauwgeers, Jan W.A. Oosterhuis, Erik Thunnissen, Marinus A. Paul, Suresh Senan, Egbert F. Smit, Cornelis G. Vos, Koen J. Hartemink |
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| Přispěvatelé: | Surgery, Radiation Oncology, Pulmonary medicine, Pathology, Cardio-thoracic surgery, CCA - Oncogenesis |
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Reoperation medicine.medical_specialty Lung Neoplasms medicine.medical_treatment Kaplan-Meier Estimate Tracheostomy Risk Factors Antineoplastic Combined Chemotherapy Protocols Humans Medicine Treatment Failure Pathological Etoposide Aged Neoplasm Staging Retrospective Studies Cisplatin Chemotherapy business.industry Remission Induction Cancer Radiotherapy Dosage Retrospective cohort study Chemoradiotherapy General Medicine Middle Aged Prognosis medicine.disease Surgery Radiation therapy Treatment Outcome Thoracotomy Oncology Female Neoplasm Recurrence Local business medicine.drug |
| Zdroj: | Vos, C G, Hartemink, K J, Blaauwgeers, J L G, Oosterhuis, J W A, Senan, S, Smit, E F, Thunnissen, E & Paul, M A 2013, ' Trimodality therapy for superior sulcus tumours: Evolution and evaluation of a treatment protocol ', European Journal of Surgical Oncology, vol. 39, no. 2, pp. 197-203 . https://doi.org/10.1016/j.ejso.2012.09.002 European Journal of Surgical Oncology, 39(2), 197-203. W.B. Saunders Ltd |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2012.09.002 |
| Popis: | Aim We studied the clinical outcomes of a trimodality protocol used for the treatment of superior sulcus tumours (SST) in a tertiary referral centre. Methods The details of all patients who underwent treatment for a SST between January 2003 and December 2009 were retrospectively analysed. Following pre-treatment staging, all patients underwent concurrent chemoradiotherapy with cisplatin/etoposide, followed by surgery. Outcomes studied were treatment-related complications, pathological response rates, recurrence rates and survival. Results Fifty-four patients were treated by chemotherapy (cisplatin/etoposide) and concurrent radiotherapy (46–66 Gy) followed by surgical resection. Minimum follow-up was 23 months. No 30-day mortality was observed. A complete (R0) resection was performed in 44 out of 54 patients. None had an R2 resection. Two-year survival was 50% (95%CI: 36.7–63.3). Patients who achieved a pathological complete response ( n = 16) had a 2-year survival of 81% (95%CI: 62.1–100.0) versus a 37% 2-year survival (95%CI: 21.5–52.1) in patients with remaining vital tumour in their resection specimens ( n = 38; P = 0.003). Five patients developed a local recurrence, and 23 patients a distant metastasis, mainly to the brain ( n = 15). Two patients died from causes unrelated to cancer. Conclusions Trimodality treatment of SST in accordance to our protocol achieved results comparable to previous reports. Pathological response rates to induction were an important prognostic factor, and distant metastasis remains a major problem. |
| Databáze: | OpenAIRE |
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