CARDIAC ARREST AFTER INTRAVENOUS ADMINISTRATION OF PROCAINE AMIDE (PRONESTYL)
| Autor: | William Weingarten, Alexander A. Doerner, Nicholas J. Galluzzi |
|---|---|
| Rok vydání: | 1954 |
| Předmět: |
Quinidine
business.industry Hydrochloride Cardiac arrhythmia Procainamide Heart Arrest Ventricular premature contractions chemistry.chemical_compound Procaine chemistry Anesthesia cardiovascular system Humans Medicine Administration Intravenous Experimental work cardiovascular diseases business Normal Sinus Rhythm Physiological Phenomena Biological Phenomena medicine.drug Procaine Amide |
| Zdroj: | Journal of the American Medical Association. 154:985 |
| ISSN: | 0002-9955 |
| DOI: | 10.1001/jama.1954.02940460017006 |
| Popis: | The quinidine-like properties of procaine on the heart have been known for a long time, but the drug is so rapidly hydrolyzed in the blood stream that the action on the heart is rather unpredictable. Lately procaine amide (Pronestyl) hydrochloride has gained wide use in cardiac arrhythmias. Procaine amide is not hydrolyzed by the body enzymes as quickly as procaine, is therefore longer acting, and has been found to be active when administered orally. Procaine amide can be given intravenously with greater safety than quinidine and on occasion may revert a cardiac arrhythmia to normal sinus rhythm even after quinidine failure. L. C. Mark and co-workers and Goldberg and Cotten have done excellent experimental work on dogs in cardiac arrhythmias and have proved the value of procaine amide in prevention and control of ventricular arrhythmias. Procaine amide was used successfully on human beings for the treatment of ventricular premature contractions |
| Databáze: | OpenAIRE |
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