Ocular adnexal lymphoma: a clinicopathologic study of a large cohort of patients with no evidence for an association with Chlamydia psittaci

Autor: Phillip Ruiz, Feying Ding, Gerald E. Byrne, Manuel F. Rosado, Sander R. Dubovy, Kenneth A. Fields, Arnold Markoe, Gale R. Walker, Izidore S. Lossos
Rok vydání: 2006
Předmět:
Adult
Male
medicine.medical_specialty
Pathology
Lymphoma
B-Cell
Clinical Trials and Observations
Immunology
Conjunctival Neoplasms
Biochemistry
Gastroenterology
Cohort Studies
Extranodal Disease
Ocular Adnexal Lymphoma
immune system diseases
Risk Factors
hemic and lymphatic diseases
Internal medicine
medicine
Humans
Disseminated disease
Stage (cooking)
Survival rate
Aged
Neoplasm Staging
Aged
80 and over
Chlamydia psittaci
Lacrimal Apparatus Diseases
biology
business.industry
Eye Neoplasms
Lymphoma
B-Cell
Marginal Zone
Cell Biology
Hematology
Middle Aged
Psittacosis
Prognosis
medicine.disease
biology.organism_classification
Combined Modality Therapy
eye diseases
Lymphoma
Survival Rate
Treatment Outcome
Chlamydophila psittaci
Orbital Neoplasms
Female
Lymphoma
Large B-Cell
Diffuse
business
Diffuse large B-cell lymphoma
Zdroj: Blood. 107:467-472
ISSN: 1528-0020
0006-4971
DOI: 10.1182/blood-2005-06-2332
Popis: Non-Hodgkin lymphomas are among the most common primary tumors occurring in the ocular adnexa. Herein, we present a 14-year single-institution experience in 62 patients with primary ocular adnexal lymphomas (OALs). Association with Chlamydia psittaci infection is examined in 57 tumor specimens.Extranodal marginal zone lymphoma (EMZL) was the most frequent histologic subtype (89%). The majority of patients with EMZL (84%) presented with stage E-extranodal (IE), however only 16% had an advanced stage. All stage IE patients were treated with local radiotherapy, whereas patients with disseminated disease received systemic therapy with or without local irradiation. All but 1 patient with EMZL achieved complete remission (CR). During a median follow-up of 52 months (range, 3-153 months), the estimated 5-year overall survival (OS) and freedom from progression (FFP) were 96% and 79%, respectively. During the follow-up, 22% of patients relapsed, mainly in extranodal sites, and 4% transformed to diffuse large B-cell lymphoma. None of the patients exhibited local orbital failure in the radiation field. None of the OAL specimens harbored C psittaci DNA.Our study demonstrates that EMZLs, accounting for the majority of primary OALs, are characterized by an indolent natural history with frequent, continuous extranodal relapses. In South Florida, OALs are not associated with C psittaci infections.
Databáze: OpenAIRE
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