Epstein-Barr Virus, Beta-Catenin, and E-cadherin in Gastric Carcinomas
| Autor: | Woo Ho Kim, In Mok Jung, Kook Lae Lee, JK Chung, Young-Joon Ahn, Byeong Gwan Kim, Je Eun Kim, Seung Chul Heo, Mee Soo Chang, Chul Woo Kim, Ki-Tae Hwang, Young A. Kim |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Gene Expression Regulation Viral Male Pathology medicine.medical_specialty Herpesvirus 4 Human Beta-catenin In situ hybridization Biology medicine.disease_cause Stomach Neoplasms Carcinoma medicine Humans In Situ Hybridization Aged Cell Nucleus Cadherin NF-kappa B General Medicine Middle Aged medicine.disease Cadherins Prognosis Epstein–Barr virus Immunohistochemistry Gene Expression Regulation Neoplastic Cell nucleus medicine.anatomical_structure Beta Catenin Catenin Cancer research biology.protein Original Article Female |
| Zdroj: | Journal of Korean Medical Science |
| ISSN: | 1598-6357 1011-8934 |
| Popis: | Activated beta-catenin is suggested to inhibit NF-kappaB activation, and we previ- ously demonstrated that NF-kappaB nuclear positivity was more frequent in Epstein- Barr virus (EBV)-infected gastric carcinomas. It is controversial that beta-catenin and E-cadherin are prognostic markers in gastric carcinomas. To define a relation- ship between beta-catenin and EBV, and the prognostic value of beta-catenin and E-cadherin, we analyzed in situ hybridization for EBV-encoded small RNAs, beta- catenin, and E-cadherin immunohistochemistry, and clinicophatological features in 111 gastric carcinomas. EBV infection was detected in seven carcinomas (6.3%); none of seven showed beta-catenin nuclear accumulation, and five out of seven revealed beta-catenin membranous loss or cytoplamic expression. Eighty cases (72.1%) showed beta-catenin alteration; i.e., loss of membrane staining in 65 (58.6 %), cytoplasmic expression in 35 (31.5%), and nuclear accumulation in 15 (13.5%). E-cadherin alteration was observed in 34 cases (30.6%) and correlated with beta- catenin alteration. On multivariate analysis, the combined immunoexpression group of beta-catenin nuclear accumulation/ E-cadherin alteration and the advanced TNM cancer stage group showed poor patient's survival ( p |
| Databáze: | OpenAIRE |
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