Identification of novel allosteric nonpeptidergic inhibitors of the human cytomegalovirus-encoded chemokine receptor US28
| Autor: | Jane Victorina, Silvina A. Fratantoni, Rob Leurs, Martine J. Smit, Iwan J. P. de Esch, Saskia Hulscher, Mark H.P. Verheij, Henry F. Vischer, Janneke W. Hulshof |
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| Přispěvatelé: | Medicinal chemistry |
| Rok vydání: | 2010 |
| Předmět: |
CCR1
Imipramine Chemokine Chemokine receptor CCR5 viruses Clinical Biochemistry Pharmaceutical Science C-C chemokine receptor type 7 C-C chemokine receptor type 6 Ligands Biochemistry Structure-Activity Relationship Viral Proteins Chemokine receptor Drug Discovery Humans Amines Molecular Biology Molecular Structure biology Chemistry Organic Chemistry virus diseases Cell biology Indenes Chemokine binding biology.protein Molecular Medicine Receptors Chemokine CCL21 |
| Zdroj: | Bioorganic and Medicinal Chemistry. Elsevier Limited Vischer, H F, Hulshof, J W, Hulscher, ST, S.A., F, Verheij, V J, Smit, M J, de Esch, I J P & Leurs, R 2009, ' Identification of novel allosteric nonpeptidergic inhibitors of the human cytomegalovirus-encoded chemokine receptor US28 ', Bioorganic and Medicinal Chemistry . https://doi.org/10.1016/j.bmc.2009.11.060 |
| ISSN: | 0968-0896 |
| Popis: | Human cytomegalovirus (HCMV) is a widespread human pathogen, possessing onco-modulatory properties. Constitutive signaling of the HCMV-encoded chemokine receptor US28 and its ability to bind a broad spectrum of chemokines might facilitate HCMV-associated tumor progression. Novel nonpeptidergic chemotypes were identified as neutral antagonists or inverse agonists on US28, that allosterically inhibit chemokine binding to US28. |
| Databáze: | OpenAIRE |
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