No Obvious Role for Suspicious Oral Pathogens in Arthritis Development
| Autor: | Hermie J. M. Harmsen, Marines du Teil Espina, Poerwati S. Rahajoe, Menke J. de Smit, Tim Stobernack, Johanna Westra, Nyoman Kertia, Elisabeth Raveling-Eelsing, Paola Lisotto, Arjan Vissink, Jan Maarten van Dijl |
|---|---|
| Přispěvatelé: | Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Microbes in Health and Disease (MHD), Translational Immunology Groningen (TRIGR), Personalized Healthcare Technology (PHT), Groningen Institute for Organ Transplantation (GIOT) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
rheumatoid arthritis
anticitrullinated protein antibodies Health Toxicology and Mutagenesis Arthritis Porphyromonas gingivalis Aggregatibacter actinomycetemcomitans Article rheumatoid factor Arthritis Rheumatoid RNA Ribosomal 16S PORPHYROMONAS-GINGIVALIS Medicine Rheumatoid factor Humans risk factors Autoantibodies Periodontitis ENVIRONMENT biology business.industry Public Health Environmental and Occupational Health Autoantibody biology.organism_classification medicine.disease MICROBIOTA GENE Rheumatoid arthritis Immunology biology.protein Antibody PERIODONTITIS business INFLAMED SURFACE-AREA |
| Zdroj: | International Journal of Environmental Research and Public Health, 18(18):9560. MDPI AG International Journal of Environmental Research and Public Health International Journal of Environmental Research and Public Health, Vol 18, Iss 9560, p 9560 (2021) Volume 18 Issue 18 |
| ISSN: | 1661-7827 |
| Popis: | A particular role for Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) has been suggested in periodontitis and rheumatoid arthritis (RA), as these bacteria could initiate the formation of rheumatoid factor (RF) and anticitrullinated protein autoantibodies (ACPA). We assessed whether serum antibodies against Pg and Aa in RA patients and non-RA controls reflect the subgingival presence of Pg and Aa, and evaluated the relationship of these antibodies to the severity of periodontal inflammation and RA-specific serum autoantibodies. In 70 Indonesian RA patients and 70 non-RA controls, the subgingival presence of Pg and Aa was assessed by bacterial 16S rRNA gene sequencing, and serum IgG levels specific for Pg and Aa were determined. In parallel, serum levels of ACPA (ACPA:IgG,IgA) and RF (RF:IgM,IgA) were measured. The extent of periodontal inflammation was assessed by the periodontal inflamed surface area. In both RA patients and the controls, the presence of subgingival Pg and Aa was comparable, anti-Pg and anti-Aa antibody levels were associated with the subgingival presence of Pg and Aa, and anti-Pg did not correlate with ACPA or RF levels. The subgingival Pg and Aa were not related to RA. No noteworthy correlation was detected between the antibodies against Pg and Aa, and RA-specific autoantibodies. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|