Supplementary Materials and Methods and Supplementary Figures 1-5 from Therapeutic HPV Cancer Vaccine Targeted to CD40 Elicits Effective CD8+ T-cell Immunity

Autor: SangKon Oh, Gerard Zurawski, Andrew G. Sikora, Sandra Zurawski, Jung-Hee Woo, Clay Beauregard, Sang-Yull Lee, LuAnn Thompson-Snipes, Seunghee Kim-Schulze, Falguni Parikh, Amelia Clark, Lance Oxford, Richard Ouedraogo, Lei Wang, Zhiqing Wang, Chao Gu, Yaming Xue, HyeMee Joo, Dorothée Duluc, Wenjie Yin
Rok vydání: 2023
Popis: Supplementary Materials and Methods: This section includes additional Materials and Methods. Supplementary Figure S1: Specificity and binding ability of αCD40 (12E12) antibody. Supplementary Figure S2. αCD40-HPV16.E6/7 can target CD40 and can thus bind to human DCs and B cells. Supplementary Figure S3. αCD40-HPV16.E6/7 can induce E6/7-specific CD8+ and CD4+ T cell responses in vivo. Supplementary Figure S4. Poly(I:C) effectively enhances antigen-specific CD8+ T cell response in human in vitro. Supplementary Figure S5. Poly(I:C) effectively enhances antigen-specific CD8+ T cell response in CD40Tg mice in vivo.
Databáze: OpenAIRE