Extensive non-redundancy in a recently duplicated developmental gene family
| Autor: | Sebastian M. Shimeld, E A Baker, Sophie P. R. Gilbert, Alison Woollard |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Gene duplication
Evolution Swine Mutant Biology Cell fate determination Taxon-restricted genes Functional redundancy 03 medical and health sciences 0302 clinical medicine Genes Duplicate QH359-425 Gene family Animals Hedgehog Proteins Genes Developmental Caenorhabditis elegans Hedgehog Gene QH540-549.5 030304 developmental biology 0303 health sciences Ecology General Medicine biology.organism_classification Evolutionary biology Hedgehog signalling Warthog family 030217 neurology & neurosurgery Function (biology) Research Article Signal Transduction |
| Zdroj: | BMC Ecology and Evolution BMC Ecology and Evolution, Vol 21, Iss 1, Pp 1-17 (2021) |
| ISSN: | 2730-7182 |
| Popis: | BackgroundIt has been proposed that recently duplicated genes are more likely to be redundant with one another compared to ancient paralogues. The evolutionary logic underpinning this idea is simple, as the assumption is that recently derived paralogous genes are more similar in sequence compared to members of ancient gene families. We set out to test this idea by using molecular phylogenetics and exploiting the genetic tractability of the model nematode,Caenorhabditis elegans,in studying the nematode-specific family of Hedgehog-related genes, the Warthogs. Hedgehog is one of a handful of signal transduction pathways that underpins the development of bilaterian animals. While having lost abona fideHedgehog gene, most nematodes have evolved an expanded repertoire of Hedgehog-related genes, ten of which reside within the Warthog family.ResultsWe have characterised their evolutionary origin and their roles inC. elegansand found that these genes have adopted new functions in aspects of post-embryonic development, including left–right asymmetry and cell fate determination, akin to the functions of their vertebrate counterparts. Analysis of various double and triple mutants of the Warthog family reveals that more recently derived paralogues are not redundant with one another, while a pair of divergent Warthogs do display redundancy with respect to their function in cuticle biosynthesis.ConclusionsWe have shown that newer members of taxon-restricted gene families are not always functionally redundant despite their recent inception, whereas much older paralogues can be, which is considered paradoxical according to the current framework in gene evolution. |
| Databáze: | OpenAIRE |
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