Reverse dynamisation: a modern perspective on Stephan Perren’s strain theory
| Autor: | Vaida Glatt, Kevin Tetsworth, Christopher H. Evans |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Fixation stability
Bone Regeneration RD1-811 Callus formation interfragmentary strain theory 0206 medical engineering Fracture site Context (language use) Diseases of the musculoskeletal system 02 engineering and technology Contemporary theory Bone and Bones Strain theory Fractures Bone Animals Humans Bony Callus Bone regeneration Fracture Healing Perspective (graphical) dynamisation fixation stability Neoclassical economics 020601 biomedical engineering animal models reverse dynamisation mechanical environment RC925-935 Surgery bone healing |
| Zdroj: | European Cells & Materials, Vol 41, Pp 668-679 (2021) |
| DOI: | 10.22203/ecm.v041a43 |
| Popis: | The present review acknowledges the tremendous impact of Stephan Perren’s strain theory, considered with respect to the earlier contributions of Roux and Pauwels. Then, it provides further insight by examining how the concept of reverse dynamisation extended Perren’s theory within a modern context. A key factor of this more contemporary theory is that it introduces variable mechanical conditions at different time points during bone healing, opening the possibility of manipulating biology through mechanics to achieve the desired clinical outcome. The discussion focusses on the current state of the art and the most recent advances made towards optimising and accelerating bone regeneration, by actively controlling the mechanical environment as healing progresses. Reverse dynamisation utilises a very specific mechanical manipulation regimen, with conditions initially flexible to encourage and expedite early callus formation. Once callus has formed, the mechanical conditions are intentionally modified to create a rigid environment under which the soft callus is quickly converted to hard callus, bridging the fracture site and leading to a more rapid union. The relevant literature, principally animal studies, was surveyed to provide ample evidence in support of the effectiveness of reverse dynamisation. By providing a modern perspective on Stephan Perren’s strain theory, reverse dynamisation perhaps holds the key to tipping the balance in favour of a more rapid and reliable union when treating acute fractures, osteotomies, non-unions and other circumstances where it is necessary to regenerate bone. |
| Databáze: | OpenAIRE |
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