COVID-19 as a trigger of irritable bowel syndrome: A review of potential mechanisms
| Autor: | Francesca Romana Ponziani, Stefano Bibbò, Antonio Gasbarrini, Carlo Romano Settanni, Gianluca Ianiro, Giovanni Cammarota, Jonathan Segal |
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| Rok vydání: | 2021 |
| Předmět: |
Opinion Review
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) SARS-CoV-2 business.industry Microbiota Gastroenterology COVID-19 General Medicine medicine.disease Irritable Bowel Syndrome Internal medicine medicine Dysbiosis Humans business Pandemics Gut-brain axis Irritable bowel syndrome |
| Zdroj: | World Journal of Gastroenterology |
| ISSN: | 1007-9327 |
| Popis: | In December 2019 a novel coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), started spreading from Wuhan city of Chinese Hubei province and rapidly became a global pandemic. Clinical symptoms of the disease range from paucisymptomatic disease to a much more severe disease. Typical symptoms of the initial phase include fever and cough, with possible progression to acute respiratory distress syndrome. Gastrointestinal manifestations such as diarrhoea, vomiting and abdominal pain are reported in a considerable number of affected individuals and may be due to the SARS-CoV-2 tropism for the peptidase angiotensin receptor 2. The intestinal homeostasis and microenvironment appear to play a major role in the pathogenesis of COVID-19 and in the enhancement of the systemic inflammatory responses. Long-term consequences of COVID-19 include respiratory disturbances and other disabling manifestations, such as fatigue and psychological impairment. To date, there is a paucity of data on the gastrointestinal sequelae of SARS-CoV-2 infection. Since COVID-19 can directly or indirectly affect the gut physiology in different ways, it is plausible that functional bowel diseases may occur after the recovery because of potential pathophysiological alterations (dysbiosis, disruption of the intestinal barrier, mucosal microinflammation, post-infectious states, immune dysregulation and psychological stress). In this review we speculate that COVID-19 can trigger irritable bowel syndrome and we discuss the potential mechanisms. |
| Databáze: | OpenAIRE |
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