Homology between human Chromosome 2p13.3 and the wobbler critical region on mouse Chromosome 11: comparative high-resolution mapping of STS and EST loci on YAC/BAC contigs
| Autor: | Dirk Korthaus, Cora S. Thiel, Harald Jockusch, Karin Resch, Thomas Schmitt-John, Melanie Ronsiek, Niels Wedemeyer, Kristin Baer, Andreas Lengeling |
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| Rok vydání: | 1998 |
| Předmět: |
Molecular Sequence Data
High resolution Nerve Tissue Proteins Locus (genetics) Biology Homology (biology) Mice GTP-Binding Proteins Malate Dehydrogenase Sequence Homology Nucleic Acid Genetics Homologous chromosome Animals Humans Cloning Molecular Myeloid Ecotropic Viral Integration Site 1 Protein Chromosomes Artificial Yeast Gene Homeodomain Proteins Otx Transcription Factors Contig Chromosome Mapping Chromosome Oncogenes Molecular biology Human genetics Neoplasm Proteins Mice Inbred C57BL rab1 GTP-Binding Proteins Chromosomes Human Pair 2 Transcription Factors |
| Zdroj: | Mammalian Genome. 9:893-898 |
| ISSN: | 1432-1777 0938-8990 |
| DOI: | 10.1007/s003359900890 |
| Popis: | Human Chr 2p13-14 and homologous regions on mouse Chrs 6 and 11 have been subjects of previous studies because they comprise the loci for several neuromuscular diseases. Here we report on high-resolution mapping of 55 STS and EST loci on human Chr 2p13.3 and of 47 markers on the corresponding region on proximal mouse Chr. 11. The maps comprise several known genes, MEIS1/Meis1, RAB1a/Rab1a, MDH1/Mor2, OTX1/Otx1, and REL on human 2p13.3 and mouse Chr 11, respectively, as well as the wobbler (wr) critical region of the mouse. Whereas a perfect correspondence was found in most of the 4-Mb region, a small rearrangement was discovered around the OTX1/Otx1 locus. The detailed STS and EST transcript maps of these regions and a further narrowing down of the mouse wr critical region to the interval between D11Mit79 and D11Mit19 allow for the selection of positional candidate genes for wr, and the exclusion of others. |
| Databáze: | OpenAIRE |
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