Sugammadex: a selective relaxant-binding agent providing rapid reversal
| Autor: | F Pühringer, Christopher Rex, Urs Adrian Bergner |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Emergency Medical Services
Sugammadex Full recovery medicine Animals Humans Anesthesia Drug Interactions Androstanols Rocuronium Cholinesterase Neuromuscular Blockade Vecuronium Bromide biology Muscle Relaxants Central business.industry Clinical Practice Anesthesiology and Pain Medicine Rapid onset biology.protein business Neuromuscular Nondepolarizing Agents gamma-Cyclodextrins medicine.drug |
| Zdroj: | Current Opinion in Anaesthesiology. 23:461-465 |
| ISSN: | 0952-7907 |
| DOI: | 10.1097/aco.0b013e32833a5413 |
| Popis: | Purpose of review Sugammadex is a new reversal agent with a unique mechanism of action in anaesthesia. Because of its rapid onset of action and its efficacy in determining neuromuscular blockade at any time, it opens up new perspectives in anaesthesia. Recent findings During the last few years, a lot of phase II and III studies have been published, investigating various groups of patients and clinical situations. Sugammadex has been shown to be a well tolerated drug, which appears to meet every challenge it is presented with in daily clinical practice. Summary Sugammadex binds amino-steroidal muscle relaxants by encapsulation. It enables rapid reversal of neuromuscular blockade at any time point and at any depth of block. Its effects are predictable and very reliable, in contrast to cholinesterase inhibitors. This opens up new perspectives in anaesthesia. Even an emergency reversal of high-dose rocuronium-induced neuromuscular blockade is possible with sugammadex and times to full recovery (TOF 0.9) are faster than after spontaneous recovery from suxamethonium. |
| Databáze: | OpenAIRE |
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