Role of prostacyclin synthase in carcinogenesis
Autor: | Chieko Yokoyama, Yuka Sasaki, Shuntaro Hara, Tsubasa Ochiai, Yukihiro Kondo, Masaya Takamura |
---|---|
Rok vydání: | 2017 |
Předmět: |
0301 basic medicine
medicine.medical_specialty Carcinogenesis Physiology Prostaglandin Peroxisome proliferator-activated receptor Prostacyclin medicine.disease_cause Biochemistry Gene Expression Regulation Enzymologic Prostacyclin synthase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cytochrome P-450 Enzyme System Biosynthesis Neoplasms Internal medicine medicine Animals Humans Pharmacology chemistry.chemical_classification biology ATP synthase Cell Biology Intramolecular Oxidoreductases 030104 developmental biology Enzyme Endocrinology chemistry 030220 oncology & carcinogenesis biology.protein Cancer research lipids (amino acids peptides and proteins) Gene Deletion medicine.drug |
Zdroj: | Prostaglandins & Other Lipid Mediators. 133:49-52 |
ISSN: | 1098-8823 |
DOI: | 10.1016/j.prostaglandins.2017.05.001 |
Popis: | Prostacyclin (PGI2) synthase (PGIS) and microsomal prostaglandin (PG) E synthase-1 (PGES-1) functionally couple with inducible cyclooxygenase-2 (COX-2) as their upstream enzymes to produce PGI2 and PGE2, respectively. Non-steroidal anti-inflammatory drugs exert their pharmacological effects including antitumor effects by the inhibition of COX-2 and thereby suppress this PG biosynthesis. PGIS is abundantly expressed in vascular endothelial and smooth muscle cells and was shown to be critical for the regulation of platelet aggregation and vascular tone. In addition to its role in vascular regulation, PGIS was shown to be frequently down-regulated in several types of cancers, and the involvement of PGIS in carcinogenesis has been suggested. In this review, we summarize the current understanding of the roles of PGIS and PGIS-derived PGI2 in carcinogenesis. |
Databáze: | OpenAIRE |
Externí odkaz: |
Pro tento záznam nejsou dostupné žádné jednotky.