Association of human adenovirus-36 in overweight Korean adults
| Autor: | Sun Ha Jee, Ha-Na Na, Jihye Kim, K. W. Shim, I. Jo, Jae-Hwan Nam, Heejin Kimm, H. S. Lee |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist Cross-sectional study Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Overweight Body Mass Index Adenovirus Infections Human Asian People Risk Factors Internal medicine Republic of Korea medicine Odds Ratio Prevalence Humans Obesity Triglycerides Nutrition and Dietetics business.industry Adenoviruses Human Cholesterol HDL Case-control study Odds ratio Middle Aged medicine.disease Confidence interval Cross-Sectional Studies Case-Control Studies Female medicine.symptom business Body mass index Biomarkers |
| Zdroj: | International journal of obesity (2005). 36(2) |
| ISSN: | 1476-5497 |
| Popis: | Although human adenovirus-36 (Ad-36) has been reported to be associated with obesity in US adults and children, Korean children and the Italian population, the association has not been found in Dutch or Belgian populations or in US military subjects. Therefore, we examined whether Ad-36 infection is associated with obesity in Korean adults.A total of 540 age- and sex-matched individuals, who were normal weight, overweight or obese, were selected from participants in routine health examinations at the Ewha Womans University Medical Center. Overweight participants were defined as those with a body mass index (BMI) of 23 ≤ BMI25 kg m(-2) and obese subjects were those with BMI ≥ 25 kg m(-2), according to the International Obesity Task Force definition. Ad-36 antibody was measured using a serum neutralization assay.Although more overweight participants than normal or obese subjects tested positive for the Ad-36 antibody (40%, 32.8% and 30%, respectively), the differences were not significant. The participants who tested positive for Ad-36 antibody had lower levels of triglycerides (TG) in each of the three groups, higher total cholesterol (TC) in the obese group and higher high-density lipoprotein-cholesterol (HDL-C) in both the normal and obese groups. The odds ratio (OR) for Ad-36 antibody positivity was greater in overweight than in normal subjects (OR=2.03; 95% confidence interval (CI), 1.16-3.55) after adjusting for age, sex and waist circumference. However, this OR was non-significant in the obese group (OR=1.56; 95% CI, 0.67-3.67).Ad-36 seems to be strongly associated with overweight, but not obese, Korean adults. |
| Databáze: | OpenAIRE |
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