Nephrotoxicity of Albendazole and Albendazole Loaded Solid Lipid Nanoparticles in Mice with Experimental Hydatidosis
Autor: | Anayatollah Salimi, Abdollah Rafiei, Mohammad Razi Jalali, Ali Jelowdar, Annahita Rezaie, Heibatullah Kalantari, Kobra Kohansal |
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Rok vydání: | 2020 |
Předmět: |
Kidney
business.industry nephrotoxicity albendazole Pharmaceutical Science RM1-950 Glutathione Pharmacology Malondialdehyde echinococcus granulosus Albendazole Nephrotoxicity chemistry.chemical_compound medicine.anatomical_structure chemistry Solid lipid nanoparticle medicine nanoparticles Therapeutics. Pharmacology General Pharmacology Toxicology and Pharmaceutics business Blood urea nitrogen hydatid cyst Homogenization (biology) medicine.drug |
Zdroj: | Advanced Pharmaceutical Bulletin, Vol 12, Iss 1, Pp 102-108 (2022) |
ISSN: | 2228-5881 |
Popis: | Purposes: Cystic echinococcosis (CE) is a serious contemporary public health problem. Different CE treatment methods are of considerable importance, with albendazole (ABZ) being one of the most preferred drugs for CE treatment and prophylaxis. In this study, we evaluated the nephrotoxicity caused by ABZ and ABZ-loaded solid lipid nanoparticles (SLNs) in mice with experimental hydatid cyst. Methods: ABZ-loaded SLNs were produced by micro-emulsification and a high shear homogenization technique. Thereafter, we evaluated the physicochemical characterization of the product. Live protoscolices were injected into mice to induce experimental hydatidosis. Mice were then treated with ABZ and ABZ-loaded SLNs. The nephrotoxicity effects were evaluated by biochemical and histopathological surveys. Results: Significantly different blood urea nitrogen (BUN) levels were observed between the two infected groups (ABZ treatment and ABZ-loaded SLN treatment) and the control group. The kidney malondialdehyde (MDA) and glutathione (GSH) levels of the infected groups were not significantly different from those of the control group. The histopathological study revealed nephropathic and pathologic changes in the ABZ and ABZ-loaded SLN groups. Conclusion: ABZ formulated for ABZ-loaded SLNs had a more prominent chemoprophylactic efficacy on CE and fewer side effects than ABZ alone. Neither ABZ nor ABZ-loaded SLNs caused significant biochemical and histopathological defects on the kidney, and all functional biochemical markers stayed within the normal range. Therefore, ABZ-loaded SLNs could be a potential new product for CE treatment. |
Databáze: | OpenAIRE |
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