Open transanal resection of low rectal stromal tumor following neoadjuvant therapy of imatinib mesylate: Report of 11 cases and review of literature

Autor:	Xinxing Li, Weijun Wang, Zhiqian Hu, Ning Su, Qiang Sun
Rok vydání:	2020
Předmět:	Male medicine.medical_specialty Gastrointestinal Stromal Tumors medicine.medical_treatment Transanal resection Anal Canal Antineoplastic Agents Metastasis 03 medical and health sciences 0302 clinical medicine Biopsy medicine Humans 030212 general & internal medicine Stromal tumor Neoadjuvant therapy Retrospective Studies medicine.diagnostic_test GiST Rectal Neoplasms business.industry General Medicine Middle Aged medicine.disease Neoadjuvant Therapy Surgery Imatinib mesylate Oncology 030220 oncology & carcinogenesis Imatinib Mesylate Anal verge Female business
Zdroj:	Asia-Pacific Journal of Clinical Oncology. 16:123-128
ISSN:	1743-7563 1743-7555
Popis:	Objective The global burden of rectal gastrointestinal stromal tumor (GIST) is increasing. However, a limited number of reports hinder our ability to reach a definitive conclusion regarding the current treatment and prognosis. In this study, we outline our experience with open transanal resection of rectal GIST following neoadjuvant therapy with imatinib mesylate (IM). Patients and methods We retrospectively analyzed 11 patients with rectal GISTs treated with neoadjuvant IM therapy and open transanal resection between April 2011 and April 2017 in Shanghai Changzheng Hospital. Results The patients had 400-600 mg/day IM once daily for a median of 7 months (range: 3-9 months). Tumor size, distance from the lower margin of the tumor to the anal verge (AV), mitotic rates and mutation analysis were assessed on pretreatment biopsy. After reassessment, all 11 patients underwent transanal R0 resection. With median follow-up of 28 months (range: 8-80 months), there was no tumor recurrence or metastasis. Conclusion Open transanal resection of rectal GIST after neoadjuvant treatment with IM has good surgical and survival outcomes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00670ad612db9c5d92077afaa43d6722 https://doi.org/10.1111/ajco.13292 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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