Supplementary Figure 1 from Exploiting Radiation-Induced Signaling to Increase the Susceptibility of Resistant Cancer Cells to Targeted Drugs: AKT and mTOR Inhibitors as an Example

Autor: C. Norman Coleman, Mansoor M. Ahmed, Jayne M. Stommel, Matthew F. Brown, Emanuel F. Petricoin, Mariaelena Pierobon, Lance Liotta, Barbara H. Rath, Sanjeewani T. Palayoor, Veit Sandfort, Molykutty J. Aryankalayil, Adeola Y. Makinde, Iris Eke
Rok vydání: 2023
DOI: 10.1158/1535-7163.22505062
Popis: Radiation schedule for the cell culture and xenograft experiments. Human prostate cancer cells were either plated or injected subcutaneously into the flanks of the right hind legs of athymic nude mice. After 24 h (in vitro) or tumors reached a tumor size of 5 mm x 5 mm (in vivo), tumors were irradiated with different fractionation regimens including a single dose of 10 Gy at day 5, 10 fractions of 1 Gy (2 fractions per day), or 5 fractions of 2 Gy (1 fraction per day). Unirradiated cells or tumors were used as control.
Databáze: OpenAIRE