The trophoblast as an integral component of a macrophage-cytokine network
| Autor: | Thomas G. Wegmann, Larry J. Guilbert, Sarah A. Robertson |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
0301 basic medicine
Macrophage colony-stimulating factor T-Lymphocytes medicine.medical_treatment Immunology Biology Giant Cells 03 medical and health sciences 0302 clinical medicine Immune system Phagocytosis medicine Animals Humans Immunology and Allergy Macrophage Acquired Immunodeficiency Syndrome Macrophages Growth factor Trophoblast Cell Biology Trophoblasts Cell biology 030104 developmental biology Cytokine medicine.anatomical_structure biology.protein Cytokines Female Tumor necrosis factor alpha Platelet-derived growth factor receptor 030215 immunology |
| Zdroj: | Immunology and Cell Biology. 71:49-57 |
| ISSN: | 0818-9641 |
| DOI: | 10.1038/icb.1993.5 |
| Popis: | The trophoblast, an epithelial cell of fetal origin that forms the physical barrier between the mother and developing conceptus, becomes a component of the host immune system during pregnancy. Of the classical immune cells, it most closely resembles the macrophage, also present in high numbers in the pregnant uterus. The macrophage and trophoblast, as cell classes, share characteristics such as phagocytosis, syncytialization, invasiveness, expression of the proteins CD4, CD14, IgG receptor (FcR), non-specific esterase, granulocyte macrophage-CSF (GM-CSF), colony stimulating factor 1 (CSF-1), interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor (TNF-alpha), transforming growth factors (TGF), platelet-alpha derived growth factor (PDGF) and receptors for these cytokines. In the uterus both cell types appear regulated by a common element, the uterine epithelium, that secretes cytokines such as CSF-1, GM-CSF, TNF alpha, TGF beta, IL-6, and leukaemia inhibitory factor (LIF) that target both macrophages and trophoblasts. The common characteristics and regulation that make teleological sense in terms of co-ordinating local uterine immunity during pregnancy may also be important in transmission of congenital diseases such as AIDS. The production by the uterine epithelium of a number of cytokines previously only associated with mononuclear phagocyte production and function predicts the existence of a similar, but broader, shared cytokine network encompassing trophoblast and the principal immune regulatory cell, the T lymphocyte. |
| Databáze: | OpenAIRE |
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