Gallbladder dysfunction in diabetes mellitus
| Autor: | Madeline Bauer, Philip W. Ralls, Ferenc Hajnal, Sylvia J. Shaw, Adina Zeidler, Jorge E. Valenzuela, Yoron Lebovitz |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Adult
medicine.medical_specialty Gallbladder Emptying Diabetic neuropathy Physiology Gastroenterology Diabetic Neuropathies Cholelithiasis Internal medicine Diabetes mellitus Diabetes Mellitus medicine Humans Cholecystokinin business.industry Gallbladder Gallstones Hepatology medicine.disease medicine.anatomical_structure Autonomic Nervous System Diseases Duodenum Female Corn Oil business Follow-Up Studies |
| Zdroj: | Digestive Diseases and Sciences. 38:490-496 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/bf01316504 |
| Popis: | To further elucidate the mechanism of impaired gallbladder emptying in diabetics with and without neuropathy, gallbladder function was assessed by ultrasonography following a medium-chain triglyceride (lipomul, 1.5 mg/kg) infusion into the duodenum and compared to that during intravenous infusion of cholecystokinin in diabetic women. Results were compared with five healthy control women. Mean (±sd) maximal percent gallbladder volume in diabetics following lipomul was reduced to 49±8% and after intravenous cholecystokinin to 47±9%, which was less than those in controls, 21±9% and 24±6%, respectively, but not significantly different. Further analysis of gallbladder emptying to lipomul differentiated two subgroups of diabetics: one subgroup (N=5) had emptying comparable to controls (responders), while the other (N=5) had very modest emptying (nonresponders). Two of the patients in the latter group had normal gallbladder emptying during exogenous cholecystokinin and their response would be compatible with visceral neuropathy. Blood levels of cholecystokinin, measured by bioassay, following lipomul and exogenous cholecystokinin were similar in controls and diabetics. Presence of diabetic neuropathy did not correlate with impaired gallbladder emptying. Follow up at 6 and 12 months of the three nonresponder diabetics revealed that no gallstones had developed and that two of them became responders to exogenous cholecystokinin. We conclude that: (1) following lipomul, about 50% of diabetics in this study have impaired gallbladder emptying, which is not strictly correlated with diabetic neuropathy; (2) this was not due to abnormal cholecystokinin release; (3) in diabetic patients with impaired gallbladder emptying another abnormality may be present in the gallbladder; and (4) impaired gallbladder contraction may not lead to gallstone formation in one-year follow-up. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink