Cardiovascular flexibility in middle-aged overweight South Asians vs. white Caucasians: Response to short-term caloric restriction

Autor: Leontine E. H. Bakker, Jacqueline T. Jonker, H.J. Lamb, A. de Roos, Hanno Pijl, Jan W. A. Smit, Ingrid M. Jazet, L.D. van Schinkel, Arend E Meinders
Rok vydání: 2015
Předmět:
Blood Glucose
Male
Body Surface Area
Endocrinology
Diabetes and Metabolism
Medicine (miscellaneous)
Type 2 diabetes
Overweight
Cardiovascular System
Body Mass Index
South Asians
Diabetes mellitus
Insulin
Prospective Studies
Pulse wave velocity
Body surface area
Magnetic resonance imaging and spectroscopy
Nutrition and Dietetics
Stroke volume
Middle Aged
Cardiovascular disease
Very low calorie diet
Adipose Tissue
Cardiology
medicine.symptom
Cardiology and Cardiovascular Medicine
Adult
medicine.medical_specialty
food.diet
Caloric restriction
Pulse Wave Analysis
White People
Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18]
food
Insulin resistance
Asian People
Internal medicine
medicine
Humans
Triglycerides
Glycated Hemoglobin
business.industry
Myocardium
Cholesterol
HDL
Cholesterol
LDL
medicine.disease
Endocrinology
Insulin Resistance
business
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases, 25(4), 403-410
Nutrition Metabolism and Cardiovascular Diseases, 25, 4, pp. 403-10
Nutrition Metabolism and Cardiovascular Diseases, 25, 403-10
ISSN: 0939-4753
Popis: Item does not contain fulltext BACKGROUND AND AIMS: South Asians have a higher risk of developing cardiovascular disease than white Caucasians. The underlying cause is unknown, but might be related to higher cardiac susceptibility to metabolic disorders. Short-term caloric restriction (CR) can be used as a metabolic stress test to study cardiac flexibility. We assessed whether metabolic and functional cardiovascular flexibility to CR differs between South Asians and white Caucasians. METHODS AND RESULTS: Cardiovascular function and myocardial triglycerides were assessed using a 1.5T-MRI/S-scanner in 12 middle-aged overweight male South Asians and 12 matched white Caucasians before and after an 8-day very low calorie diet (VLCD). At baseline South Asians were more insulin resistant than Caucasians. Cardiac dimensions were smaller, despite correction for body surface area, and pulse wave velocity (PWV) in the distal aorta was higher in South Asians. Systolic and diastolic function, myocardial triglycerides and pericardial fat did not differ significantly between groups. After the VLCD body weight reduced on average by 4.0 +/- 0.2 kg. Myocardial triglycerides increased in both ethnicities by 69 +/- 18%, and diastolic function decreased although this was not significant in South Asians. However, pericardial fat and PWV in the proximal and total aorta were reduced in Caucasians only. CONCLUSION: Myocardial triglyceride stores in middle-aged overweight and insulin resistant South Asians are as flexible and amenable to therapeutic intervention by CR as age-, sex- and BMI-matched but less insulin resistant white Caucasians. However, paracardial fat volume and PWV showed a differential effect in response to an 8-day VLCD in favor of Caucasians. CLINICAL TRIAL REGISTRATION: NTR 2473 (URL: http://www.trialregister.nl/trialreg/admin/rctsearch.asp?Term=2473).
Databáze: OpenAIRE
Externí odkaz: