Sensitivity of Rabies Virus to Type I Interferon Is Determined by the Phosphoprotein Gene

Autor:	Naoto Ito, Kenta Shimizu, Nobuyuki Minamoto, Makoto Sugiyama
Rok vydání:	2006
Předmět:	Rabies Immunology Virulence Biology medicine.disease_cause Microbiology Virus Mice Interferon Virology Drug Resistance Viral medicine Animals Gene Viral Structural Proteins Strain (chemistry) Rabies virus Phosphoproteins Molecular biology Phosphoprotein Interferon Type I Interferon type I Molecular Chaperones medicine.drug
Zdroj:	Microbiology and Immunology. 50:975-978
ISSN:	0385-5600
Popis:	The growth of a virulent strain of fixed rabies virus, Nishigahara, in mouse neuroblastoma NA cells treated with type I interferon (IFN) was compared with that of a derivative avirulent strain, Ni-CE. Nishigahara strain was slightly sensitive to IFN treatment but still grew more efficiently than did Ni-CE strain in IFN-treated NA cells. Furthermore, a virulent chimeric virus with the phosphoprotein gene from Nishigahara strain in the Ni-CE genome was less sensitive to IFN treatment than was Ni-CE strain, indicating that the IFN sensitivity is determined by the phosphoprotein gene of the virus.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0063fc1f63269c4edb3a3739ff69e110 https://doi.org/10.1111/j.1348-0421.2006.tb03875.x Zobrazit plný text záznamu Plný text