Efficacy of lapatinib monotherapy on occult breast cancer presenting with cutaneous metastases: A case report
| Autor: | Hidenori Kamio, Kei Aoyama, Hiroko Miura, Tetsuya Oochi, Shingo Kameoka, Masako Nishizawa, Eiichiro Noguchi, Masako Tamaki, Takako Kamio |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology serum human epidermal growth factor receptor 2 Lymph node biopsy Lapatinib Gastroenterology Breast cancer Internal medicine cutaneous metastases medicine skin and connective tissue diseases Lymph node lapatinib monotherapy medicine.diagnostic_test integumentary system business.industry Cancer Articles occult breast cancer medicine.disease Axilla medicine.anatomical_structure Oncology Skin biopsy Lymph business medicine.drug |
| Zdroj: | Oncology Letters |
| ISSN: | 1792-1082 1792-1074 |
| Popis: | The case of a 72-year-old female who identified a lymph node enlargement in the left axilla is reported in the present study. A lymph node biopsy revealed a metastatic adenocarcinoma of the axillary lymph node. Following various assessments, the patient was diagnosed with occult breast cancer and lymph node metastases, for which treatment was initiated. Trastuzumab monotherapy was administered as the patient was elderly, positive for the hepatitis B virus and exhibited the following immunostaining/immunohistochemical analysis results: Estrogen receptor (ER) negative (-), progesterone receptor (PgR) negative (-) and human epidermal growth factor receptor 2 (HER2) positive (3+). Breast ultrasonography was performed 10 months after the initial trastuzumab administration and the left axillary lymph node enlargement had reduced in size and severity. However, a skin rash (erythema) was observed encompassing the left breast and extending into the axilla. As determined by the result of a skin biopsy of this area, the patient was diagnosed with occult breast cancer with cutaneous metastases. The immunohistochemical analysis results obtained from the skin biopsy were similar to those obtained from the lymph nodes: ER (-), PgR (-) and HER2 (3+). Therefore, the patient was switched from trastuzumab to lapatinib monotherapy. The erythema completely disappeared after two months of treatment. At present (34 months following lapatinib monotherapy initiation) no new lesions or severe side-effects have been observed. |
| Databáze: | OpenAIRE |
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