Renal safety of two analgesics used over the counter: Ibuprofen and aspirin
| Autor: | Sharon L Bonney, Diane A Hedrich, Robert S Northington, Barry R Walker |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
medicine.medical_specialty Analgesic Renal function Ibuprofen Pharmacology Kidney Blood Urea Nitrogen law.invention Arthritis Rheumatoid Double-Blind Method law Oxaprozin Internal medicine Osteoarthritis medicine Humans Pharmacology (medical) Aged Clinical Trials as Topic Aspirin Clinical pharmacology business.industry Hepatobiliary disease Middle Aged medicine.disease Creatinine Rheumatoid arthritis Propionates business medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics. 40:373-377 |
| ISSN: | 1532-6535 0009-9236 |
| DOI: | 10.1038/clpt.1986.193 |
| Popis: | The incidence of potentially serious drug-related elevations of BUN or serum creatinine was examined among 1468 patients with rheumatoid arthritis or osteoarthritis who took daily therapeutic doses of aspirin, ibuprofen, or Oxaprozin, an investigational nonsteroidal antiinflammatory drug (NSAID), in multicenter clinical trials. Algorithms were developed to identify patients with potentially important elevations of these renal laboratory parameters and to assess the possible relation between these elevations and the study drugs. All three drugs were associated with a low (4% to 6%) incidence of potentially significant elevations in renal function parameters. Changes considered serious occurred in only three ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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