Association between complicated liver cirrhosis and the risk of hepatocellular carcinoma in Taiwan
| Autor: | Ming-Kun Ku, Lan-Ting Yuan, Wei-Chen Tai, Tsung-Hsing Hung, Deng-Chyang Wu, Seng-Howe Nguang, Seng-Kee Chuah, Kai-Lung Tsai, Pin-I Hsu, Kuo-Lun Tseng, Shih-Cheng Yang, Chien-Ning Hsu, Chih-Ming Liang, Jiunn-Wei Wang, Cheng-Kun Wu |
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| Rok vydání: | 2017 |
| Předmět: |
Liver Cirrhosis
Male Cirrhosis lcsh:Medicine Blood Pressure Pathology and Laboratory Medicine Gastroenterology Vascular Medicine Cohort Studies Geographical Locations 0302 clinical medicine Endocrinology Liver Cirrhosis Alcoholic Risk Factors Ascites Medicine and Health Sciences lcsh:Science Hepatic encephalopathy education.field_of_study Multidisciplinary Liver Diseases Hazard ratio Liver Neoplasms Middle Aged Hyperlipidemia Liver Oncology 030220 oncology & carcinogenesis Hepatocellular carcinoma Hypertension 030211 gastroenterology & hepatology Female medicine.symptom Research Article Adult medicine.medical_specialty Carcinoma Hepatocellular Asia Endocrine Disorders Population Taiwan Hemorrhage Gastroenterology and Hepatology Carcinomas 03 medical and health sciences Signs and Symptoms Diagnostic Medicine Internal medicine Gastrointestinal Tumors medicine Diabetes Mellitus Humans Risk factor education Aged Proportional Hazards Models Proportional hazards model business.industry lcsh:R Cancers and Neoplasms Hepatocellular Carcinoma medicine.disease Metabolic Disorders People and Places lcsh:Q business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 7, p e0181858 (2017) |
| ISSN: | 1932-6203 |
| Popis: | Hepatic encephalopathy, ascites, and variceal bleeding are the three major complications of cirrhosis. It is well known that cirrhosis is the most important risk factor of hepatocellular carcinoma (HCC). However, little is known about whether the severity of liver cirrhosis has an effect on the incidence of HCC. This population-based cohort study aimed to explore the association between complicated cirrhosis and HCC, and identify the risk factors of HCC in patients with complicated cirrhosis. Data of the years 1997-2011 were extracted from the National Health Insurance Research Database of Taiwan. A total of 2568 patients with complicated cirrhosis without HCC at baseline were enrolled. After propensity score matching, another 2568 patients with non-complicated cirrhosis were included. Hazards Cox regression analysis by using a competing risk regression model to control for possible confounding factors was utilized to estimate the association of the complications of liver cirrhosis with the risk of HCC. We observed by using competing risk analysis that the adjusted hazard ratio (HR) for developing HCC during the follow-up period after the initial hospitalization was higher among the patients with baseline complicated cirrhosis than in those with uncomplicated cirrhosis (HR, 1.23; 95% confidence interval, CI, 1.10-1.37, p |
| Databáze: | OpenAIRE |
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