Platinum(II) and Copper(II) complexes of asymmetric halogen-substituted [NN'O] ligands: Synthesis, characterization, structural investigations and antiproliferative activity

Autor:	Hadi Amiri Rudbari, Arezoo Saadati, Mahnaz Aryaeifar, Olivier Blacque, Jose V. Cuevas-Vicario, Rui Cabral, Luis R. Raposo, Alexandra R. Fernandes
Přispěvatelé:	University of Zurich, Amiri Rudbari, Hadi
Rok vydání:	2021
Předmět:	10120 Department of Chemistry 1303 Biochemistry Cell Survival Antineoplastic Agents Apoptosis Ligands Biochemistry Structure-Activity Relationship Halogens Coordination Complexes 540 Chemistry Drug Discovery 1312 Molecular Biology Humans DNA Cleavage Molecular Biology Cells Cultured Cell Proliferation Platinum Dose-Response Relationship Drug Molecular Structure 3002 Drug Discovery Organic Chemistry Drug Screening Assays Antitumor Copper 1605 Organic Chemistry
Zdroj:	Bioorganic chemistry. 119
ISSN:	1090-2120
Popis:	In order to better understand the effect of structure, halogen substitution, metal ions and ligand flexibility on antiproliferative activity, eight Cu(II) complexes and eight Pt(II) complexes were obtained of 2,4-X
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005dfe12f655619f3ea50e9b26953f0e https://pubmed.ncbi.nlm.nih.gov/34959175 Zobrazit plný text záznamu Full Text from ScienceDirect