Bioactive Ibuprofen-Loaded PLGA Coatings for Multifunctional Surface Modification of Medical Devices
| Autor: | Anca Roseanu, Gianina Popescu-Pelin, Gabriel Socol, Anisoara Cimpean, Valentina Mitran, Paula E. Florian, Oana Gherasim, Madalina Icriverzi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
long-term release
keratinocytes Materials science Polymers and Plastics Organic chemistry Article chemistry.chemical_compound QD241-441 topical use fibroblasts medicine Copolymer biodegradable coating metallic implants technology industry and agriculture General Chemistry Ibuprofen macrophages Clinical Practice PLGA chemistry Biodegradable coating Drug release Surface modification Swelling medicine.symptom Biomedical engineering medicine.drug |
| Zdroj: | Polymers Volume 13 Issue 9 Polymers, Vol 13, Iss 1413, p 1413 (2021) |
| ISSN: | 2073-4360 |
| DOI: | 10.3390/polym13091413 |
| Popis: | To modulate the biofunctionality of implantable medical devices commonly used in clinical practice, their surface modification with bioactive polymeric coatings is an attractive and successful emerging strategy. Biodegradable coatings based on poly(lactic acid-co-glycolic acid), PLGA, represent versatile and safe candidates for surface modification of implantable biomaterials and devices, providing additional tunable ability for topical delivery of desired therapeutic agents. In the present study, Ibuprofen-loaded PLGA coatings (PLGA/IBUP) were obtained by using the dip-coating and drop-casting combined protocol. The composite materials demonstrated long-term drug release under biologically simulated dynamic conditions. Reversible swelling phenomena of polymeric coatings occurred in the first two weeks of testing, accompanied by the gradual matrix degradation and slow release of the therapeutic agent. Irreversible degradation of PLGA coatings occurred after one month, due to copolymer’s hydrolysis (evidenced by chemical and structural modifications). After 30 days of dynamic testing, the cumulative release of IBUP was ~250 µg/mL. Excellent cytocompatibility was revealed on human-derived macrophages, fibroblasts and keratinocytes. The results herein evidence the promising potential of PLGA/IBUP coatings to be used for surface modification of medical devices, such as metallic implants and wound dressings. |
| Databáze: | OpenAIRE |
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