Therapeutic Approach of a High Functioning Individual With Traumatic Brain Injury and Subsequent Emotional Volatility With Features of Pathological Laughter and Crying With Dextromethorphan/Quinidine
| Autor: | Dynela Garcia-Baran, Michelle Geers, Thomas M. Johnson, Joyce Wagner, Joann Shen |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Pseudobulbar affect Traumatic brain injury Crying Dextromethorphan/Quinidine Dextromethorphan Drug Administration Schedule Stress Disorders Post-Traumatic 03 medical and health sciences 0302 clinical medicine Humans Medicine Affective Symptoms Clinical Case Report 030212 general & internal medicine Amyotrophic lateral sclerosis Brain Concussion Dose-Response Relationship Drug Laughter business.industry Multiple sclerosis General Medicine medicine.disease Quinidine Drug Combinations Disinhibition Brain Injuries Anesthesia medicine.symptom business 030217 neurology & neurosurgery Research Article medicine.drug |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| DOI: | 10.1097/md.0000000000002886 |
| Popis: | Pathological laughing and crying, or pseudobulbar affect (PBA), has been described in patients with neurological disorders such as multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease, stroke, and traumatic brain injury (TBI) since the 19th century (Schiffer 2005). The syndrome is characterized by inappropriate episodes of laughing or crying after minor stimuli. It was first coined a disinhibition of cortical control by Kinnier Wilson in 1924. It was observed in brain disease and seen with mild TBI. It can impair social and occupational function and is largely underrecognized in clinical settings. PBA is usually treated with antidepressants and dopaminergic agents. In this case we treated a military recruit with TBI with Nuedexta—a dextromethorphan/Quinidine derivative with a subsequent decrease in his episodes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|