The temporal relationship between growth hormone and slow wave sleep is weaker after menopause
| Autor: | Olli Polo, Sari-Leena Himanen, Atte Joutsen, Päivi Polo-Kantola, Arho Virkki, Kerttu Irjala, Tarja Porkka-Heiskanen, Nea Kalleinen |
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| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Time Factors medicine.drug_class Polysomnography medicine.medical_treatment menopause 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Double-Blind Method Internal medicine estrogen medicine Humans slow wave sleep sleep Slow-wave sleep Sleep Stages hormone therapy Human Growth Hormone Estrogen Replacement Therapy Case-control study Electroencephalography General Medicine Middle Aged medicine.disease Menopause Endocrinology Estrogen Case-Control Studies growth hormone Female Hormone therapy Sleep onset Psychology 030217 neurology & neurosurgery Blood sampling |
| Zdroj: | Kalleinen, N, Virkki, A, Polo, O, Himanen, S-L, Irjala, K, Joutsen, A, Porkka-Heiskanen, T & Polo-Kantola, P 2012, ' The temporal relationship between growth hormone and slow wave sleep is weaker after menopause ', Sleep Medicine, vol. 13, no. 1, pp. 96-101 . https://doi.org/10.1016/j.sleep.2011.05.010 |
| ISSN: | 1389-9457 |
| DOI: | 10.1016/j.sleep.2011.05.010 |
| Popis: | ObjectiveTo study the temporal association between growth hormone (GH) and slow wave sleep (SWS) in middle-aged women.MethodsSeventeen premenopausal and 18 postmenopausal women were studied using all-night polygraphic sleep recordings and blood sampling at 20-min intervals. The postmenopausal women were re-studied after six months on hormone therapy (HT) according to a randomized, double-blind, placebo-controlled protocol.ResultsThe total sleep time (premenopausal 361.9 ± 81.5 min, postmenopausal 358 ± 67.7 min) and the percentages of the sleep stages did not differ between pre- and postmenopausal women. In postmenopausal women the first GH peak after sleep onset occurred later and with a more variable time interval compared to premenopausal women. The percentage of SWS was highest 40–20 min prior to the first GH peak after sleep onset in both groups with a higher SWS proportion in premenopausal women (p = 0.048), although the total SWS percent for night did not differ. HT did not affect the distribution of SWS in postmenopausal women.ConclusionsThe temporal relationship between GH and SWS in premenopausal women is less robust after menopause and is not improved with HT. |
| Databáze: | OpenAIRE |
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