Non-aversive photographic measurement method for subcutaneous tumours in nude mice
| Autor: | Cecilia Carbone, Agustina Resasco, Ana Cristina Carranza Martin, Silvina L. Diaz, Miguel Ángel Ayala |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
mice 040301 veterinary sciences Biología Mice Nude Welfare Soft Tissue Neoplasms 0403 veterinary science Rodent Diseases 03 medical and health sciences Mice Otras Ciencias Veterinarias tumour model Photography Medicine Animals refinement non-aversive 030304 developmental biology 0303 health sciences Measurement method General Veterinary business.industry Ciencias Veterinarias NUDE 04 agricultural and veterinary sciences TUMORS Specific Pathogen-Free Organisms Tumor Burden CIENCIAS AGRÍCOLAS Calipers Animal Science and Zoology Tumour volume Female PHOTOGRAPHIC business Nuclear medicine |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| Popis: | We have developed a new method for the measurement of subcutaneous tumour volume which consists in taking photographs of mice in their home cages, to refine the standard method of measurement with calipers. We consider this new method to be non-aversive, as it may be more compatible with mice behavioural preferences and, therefore, improve their welfare. Photographs are captured when mice voluntarily go into an acrylic tube containing graph paper that is later used as a scale. Tumour volumes measured with the caliper and the non-aversive photographic method were compared to those obtained by water displacement volume and weight. Behavioural and physiological changes were evaluated to assess animal welfare. Significant differences were found between measurements obtained with the caliper and the non-aversive photographic method, v. the reference volume acquired by water displacement (P Instituto de Genética Veterinaria |
| Databáze: | OpenAIRE |
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