| Autor: |
Jorge Vialard, Vladimir Chupakhin, Yves Moreau, Günter Klambauer, Shantanu Singh, Marvin Steijaert, Adam Arany, Sepp Hochreiter, Anne E. Carpenter, Hugo Ceulemans, Roel Wuyts, Emmanuel Gustin, Jörg K. Wegner, Peter Jacobus Johannes Antonius Buijnsters, A. Vapirev, Ingrid Velter, Jaak Simm, Yolanda T. Chong |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
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| DOI: |
10.1101/108399 |
| Popis: |
We repurpose a High-Throughput (cell) Imaging (HTI) screen of a glucocorticoid receptor assay to predict target protein activity in multiple other seemingly unrelated assays. In two ongoing drug discovery projects, our repurposing approach increased hit rates by 60- to 250-fold over that of the primary project assays while increasing the chemical structure diversity of the hits. Our results suggest that data from available HTI screens are a rich source of information that can be reused to empower drug discovery efforts. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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