Pain sensitivity increases with sleep disturbance under predictable chronic mild stress in mice
| Autor: | Yoshizo Matsuka, Yoshitaka Suzuki, Noriyuki Shimizu, Junhel Dalanon, Kazuo Okura, Tetsuya Shiuchi, Sachiko Chikahisa, Parimal Chavan, Hiroyoshi Sei |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Pain Threshold Sleep Wake Disorders medicine.medical_specialty Science Thalamus Pain Sleep REM Real-Time Polymerase Chain Reaction Non-rapid eye movement sleep Article 03 medical and health sciences Trigeminal ganglion Mice 0302 clinical medicine Facial Pain Internal medicine Threshold of pain medicine Animals Wakefulness Sleep disorder Multidisciplinary business.industry Electroencephalography medicine.disease Sleep in non-human animals Mice Inbred C57BL 030104 developmental biology Endocrinology Hypothalamus Hyperalgesia Medicine Sleep Deprivation medicine.symptom business Sleep Corticosterone Stress and resilience 030217 neurology & neurosurgery Locomotion |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Even though it has been well documented that stress can lead to the development of sleep disorders and the intensification of pain, their relationships have not been fully understood. The present study was aimed at investigating the effects of predictable chronic mild stress (PCMS) on sleep–wake states and pain threshold, using the PCMS rearing conditions of mesh wire (MW) and water (W) for 21 days. Exposure to PCMS decreased the amount of non-rapid eye movement (NREM) sleep during the dark phase. Moreover, the chronicity of PCMS decreased slow-wave activity (SWA) during NREM sleep in the MW and W groups in both the light and dark phases. Mechanical and aversively hot thermal hyperalgesia were more intensified in the PCMS groups than the control. Higher plasma corticosterone levels were seen in mice subjected to PCMS, whereas TNF-α expression was found higher in the hypothalamus in the W and the trigeminal ganglion in the MW group. The W group had higher expression levels of IL-6 in the thalamus as well. The PCMS paradigm decreased SWA and may have intensified mechanical and thermal hyperalgesia. The current study also suggests that rearing under PCMS may cause impaired sleep quality and heightened pain sensation to painful mechanical and aversively hot thermal stimuli. |
| Databáze: | OpenAIRE |
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