Prognostic significance of DNA ploidy in mucoepidermoid carcinoma
| Autor: | H. B. Hellquist, P. Gemryd, Bo Nordenskjöld, P. G. Lundquist, M. Tytor |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Biology Salivary Glands Mucoepidermoid carcinoma Carcinoma medicine Humans Stage (cooking) Lymph node Neoplasm Staging Univariate analysis Salivary gland DNA Patterns General Medicine DNA Neoplasm Middle Aged medicine.disease Aneuploidy Flow Cytometry Prognosis Salivary Gland Neoplasms Combined Modality Therapy Diploidy medicine.anatomical_structure Otorhinolaryngology Carcinoma Mucoepidermoid Female Radiotherapy Adjuvant Ploidy |
| Zdroj: | European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 254(4) |
| ISSN: | 0937-4477 |
| Popis: | Thirty-four mucoepidermoid carcinomas were studied retrospectively with regard to histological and clinical parameters. In 28 of the tumors DNA patterns were also assessed using flow cytometry. Twenty-two of the 28 tumors (79%) were DNA diploid and 6 (21%) DNA aneuploid. Two tumors (7%) showed intratumoral DNA as indicated by different stemlines in specimens investigated from different parts of the tumor. DNA ploidy correlated significantly with cervical lymph node status (P < 0.01), but not with tumor size or histological grade. The mean S-phase value was 2.7% and was significantly higher in aneuploid samples than in diploid ones (P < 0.05). The recurrence rate was significantly lower for patients with stage I and II tumor compared with those with stage III and IV disease (P < 0.01). Five aneuploid tumors showed significantly higher recurrence rates (5/6) than the diploid ones (1/22) (P < 0.01). In univariate analysis for survival, only N stage tumor (P < 0.05) and tumor DNA ploidy (P < 0.0003) had significant prognostic influence. Thus, DNA ploidy seems to be a valuable parameter for evaluating the biological behavior of mucoepidermoid carcinomas of the salivary glands. |
| Databáze: | OpenAIRE |
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