Mitochondrial DNA Dynamics in Reprogramming to Pluripotency
| Autor: | Michael A. Teitell, Natasha M. Carlson, Alexander J. Sercel, Alexander N. Patananan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0303 health sciences
Mitochondrial DNA Homoplasmy Cellular differentiation Induced Pluripotent Stem Cells Cell Biology Mitochondrion Biology Cellular Reprogramming DNA Mitochondrial Mitochondrial Dynamics Genome Article Heteroplasmy Mitochondria Cell biology 03 medical and health sciences 0302 clinical medicine Animals Induced pluripotent stem cell Reprogramming 030217 neurology & neurosurgery 030304 developmental biology |
| Zdroj: | Trends Cell Biol |
| ISSN: | 0962-8924 |
| DOI: | 10.1016/j.tcb.2020.12.009 |
| Popis: | Mammalian cells, with the exception of erythrocytes, harbor mitochondria, which are organelles that provide energy, intermediate metabolites, and additional activities to sustain cell viability, replication, and function. Mitochondria contain multiple copies of a circular genome called mitochondrial DNA (mtDNA), whose individual sequences are rarely identical (homoplasmy) because of inherited or sporadic mutations that result in multiple mtDNA genotypes (heteroplasmy). Here, we examine potential mechanisms for maintenance or shifts in heteroplasmy that occur in induced pluripotent stem cells (iPSCs) generated by cellular reprogramming, and further discuss manipulations that can alter heteroplasmy to impact stem and differentiated cell performance. This additional insight will assist in developing more robust iPSC-based models of disease and differentiated cell therapies. |
| Databáze: | OpenAIRE |
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