Chronic cytomegalovirus infection, immunodeficiency, and monoclonal gammopathy-antigen-driven malignancy?
| Autor: | Richard Hong, Sheldon Horowitz, Judith C. Lovchik, Alvin Davis, Ted Groshong |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Erythrocytes
medicine.medical_treatment Congenital cytomegalovirus infection Malignancy Antigen Immunity Hypergammaglobulinemia Humans Medicine Distribution (pharmacology) Lymphocytes Antigens Immunodeficiency Skin Tests Severe combined immunodeficiency business.industry Immunologic Deficiency Syndromes Infant Newborn Infant Cytotoxicity Tests Immunologic medicine.disease Virology Immune Adherence Reaction Thymus transplantation Immunoglobulin G Antibody Formation Chronic Disease Cytomegalovirus Infections Pediatrics Perinatology and Child Health Immunology Mitogens business |
| Zdroj: | The Journal of Pediatrics. 88:217-223 |
| ISSN: | 0022-3476 |
| DOI: | 10.1016/s0022-3476(76)80985-7 |
| Popis: | An infant with severe combined immunodeficiency had normal numbers of lymphocytes which bore E rosette and surface Ig markers in an appropriate distribution. However, only minimal responsivity to in vitro stimulation by mitogens and allogeneic cells, and none to antigens could be elicited; functional antibody responses were also nil, except to cytomegalovirus. Intrauterine-acquired cytomegalovirus may have caused his immune dysfunction, although the possibility of a postnatal infection cannot be excluded. Therapy with transfer factor and thymus transplantation was unsuccessful in restoring immunity and may have aggravated a pre-existing monoclonal gammopathy. It is possible that the monoclonal protein was derived from B-cells transplacentally received from the patient's mother. |
| Databáze: | OpenAIRE |
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