Behavioral reinforcement of long-term potentiation is impaired in aged rats with cognitive deficiencies
| Autor: | J Ravelo, Julietta U. Frey, Jorge A. Bergado, J.C. Rosillo, W. Almaguer |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Senescence Aging Behavior Animal Water Deprivation General Neuroscience Dentate gyrus Long-Term Potentiation Cognitive disorder Drinking Long-term potentiation Cognition medicine.disease Rats Rats Sprague-Dawley medicine.anatomical_structure Synaptic plasticity medicine Animals Cognition Disorders Reinforcement Psychology Reinforcement Psychology Neuroscience Basolateral amygdala |
| Zdroj: | Neuroscience. 108:1-5 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/s0306-4522(01)00520-6 |
| Popis: | Behavioral stimuli with emotional/motivational content can reinforce long-term potentiation in the dentate gyrus, if presented within a distinct time window. A similar effect can be obtained by stimulating the basolateral amygdala, a limbic structure related to emotions. We have previously shown that aging impairs amygdala–hippocampus interactions during long-term potentiation. In this report we show that behavioral reinforcement of long-term potentiation is also impaired in aged rats with cognitive deficits. While among young water-deprived animals drinking 15 min after induction of long-term potentiation leads to a significant prolongation of potentiation, cognitively impaired aged rats are devoid of such reinforcing effects. In contrast, a slight but statistically significant depression develops after drinking in this group of animals. We suggest that an impaired mechanism of emotional/motivational reinforcement of synaptic plasticity might be functionally related to the cognitive deficits shown by aged animals. |
| Databáze: | OpenAIRE |
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