Role ofChlamydia trachomatisin Miscarriage
| Autor: | Gilbert Greub, Patrick Hohlfeld, Yvan Vial, Nicole Borel, Andreas Pospischil, Serafin Blumer, Maria-Chiara Osterheld, David Baud, Genevieve Goy, Katia Jaton |
|---|---|
| Přispěvatelé: | University of Zurich, Greub, Gilbert |
| Rok vydání: | 2011 |
| Předmět: |
placental infection
Sexually transmitted disease Placenta miscarriage lcsh:Medicine Chlamydia trachomatis Abortion medicine.disease_cause 2726 Microbiology (medical) Miscarriage Serology 0302 clinical medicine Pregnancy Prospective Studies 030212 general & internal medicine bacteria 0303 health sciences Obstetrics sexually transmitted disease Abortion Spontaneous/etiology Abortion Spontaneous/immunology Adult Chlamydia Infections/complications Chlamydia trachomatis/genetics Chlamydia trachomatis/immunology DNA Bacterial/analysis Female Humans Multivariate Analysis Placenta/microbiology Regression Analysis 3. Good health medicine.anatomical_structure Products of conception DNA Bacterial medicine.medical_specialty 10184 Institute of Veterinary Pathology lcsh:Infectious and parasitic diseases 03 medical and health sciences medicine lcsh:RC109-216 Gynecology 030306 microbiology business.industry Research lcsh:R 2725 Infectious Diseases Chlamydia Infections medicine.disease abortion Abortion Spontaneous 570 Life sciences biology adverse pregnancy outcome business 2713 Epidemiology |
| Zdroj: | Emerging Infectious Diseases, Vol 17, Iss 9, Pp 1630-1635 (2011) Emerging Infectious Diseases, vol. 17, no. 9, pp. 1630-1635 Emerging Infectious Diseases |
| ISSN: | 1080-6040 |
| DOI: | 10.3201/eid1709.100865 |
| Popis: | TOC Summary: Women experiencing miscarriage should be screened for C. trachomatis. To determine the role of Chlamydia trachomatis in miscarriage, we prospectively collected serum, cervicovaginal swab specimens, and placental samples from 386 women with and without miscarriage. Prevalence of immunoglobulin G against C. trachomatis was higher in the miscarriage group than in the control group (15.2% vs. 7.3%; p = 0.018). Association between C. trachomatis–positive serologic results and miscarriage remained significant after adjustment for age, origin, education, and number of sex partners (odds ratio 2.3, 95% confidence interval 1.1–4.9). C. trachomatis DNA was more frequently amplified from products of conception or placenta from women who had a miscarriage (4%) than from controls (0.7%; p = 0.026). Immunohistochemical analysis confirmed C. trachomatis in placenta from 5 of 7 patients with positive PCR results, whereas results of immunohistochemical analysis were negative in placenta samples from all 8 negative controls tested. Associations between miscarriage and serologic/molecular evidence of C. trachomatis infection support its role in miscarriage. |
| Databáze: | OpenAIRE |
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